ID G3UQ69_MELGA Unreviewed; 1933 AA.
AC G3UQ69;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|Ensembl:ENSMGAP00000017737.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017737.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000017737.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000017737.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSMGAT00000019921.2; ENSMGAP00000017737.2; ENSMGAG00000005856.3.
DR GeneTree; ENSGT00940000153617; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000001645; Chromosome 30.
DR Bgee; ENSMGAG00000005856; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1272..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 228..310
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..407
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 412..506
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 510..611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 616..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..826
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 827..920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 925..1021
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1025..1109
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1378..1633
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1553..1624
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1665..1924
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1842..1915
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 549..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1933 AA; 216822 MW; 1027140BCC00A1C4 CRC64;
LSPAWKQILS VLVPIMIFFL FLFILKGPPV FIKKPVDQIG VSGGVASFVC QATGDPKPRV
TWNKKGKKVN SQRFETIEFD ESAGAVLRIQ PLRTPRDENI YECVAQNPHG EVTVHAKLTV
LREDQLPPGF PNIDMGPQLK VVERTRTATM LCAASGNPDP EITWFKDFLP VDPSTSNGRI
KQLRSGGLQI ESSEETDQGK YECVASNSAG VRYSSPANLY VRVRRVAPRF SILPVSHEIM
PGGNVNITCV AVGSPMPYVK WMQGAEDLTP EDDMPVGRNV LELTDVKDSA NYTCVAMSSL
GVIEAVAQIT VKCKGVLLGR PVVTETTATS ITITWDSGNP DPVSYYVIEY KSKSQDGPYQ
IKEDITTTRY SIGGLSPNSE YEIWVSAVNS IGQGPPSESV VTRTGEQAPA SAPRNVQGRM
LSSTTMIIQW EEPVEPNGQI RGYRVYYTME PDQPVSNWQK HNVDDSLLTT VGSLLEDETY
TVRVLAFTSV GDGPLSDPIQ VKTQQGVPGQ PMNFRAEAKT ETSIMLSWSP PRQEIIVKYE
LLFKEGDHGR EVSPERSSTT GWGPEENFEP TTSFTVEGLK PNTEYVFRLA ARSALGLGAF
TPEVRERTLQ SKPSAPPQDI KCVSTRSTAI LVSWRPPPAE SQNGVLAGYS VYYRALDSED
TELKEVNDIP PTTSQILLES LEKWTEYRIT VVAHTEVGPG PESSPVIVRT DEDVPSAPPR
KVEVEVLNST AIQVFWRSPV QNRQHGQIRG YQVHYVRMEN GEARGLPQIK DIMLADAQWE
TDDTAEYEMV IAGLQPETAY SITVAAYTMK GDGARSKPKV VTTKGAVPGK PILSVHQTEE
NTLLVKWEPP LDAEGQVMGY RLQFGRKDVD PLATLEFSAL EDKYTAPSIH KGATYVFKLA
VKSRAGFGEE AVQELTTPED IPKGYPQILE ASNITSMSVQ FGWLPPVLAE RNGAIVKYTV
AYREAGSPGN PLEKDLPPSP ENSYTLNGLK PNTAYDVKIR AHTSKGPGPY SPTVQYRTFQ
LDQVLPKNFK VKMVTKTSVL LSWEFPENYN SPTPYKIQYN GLNVDVDGRT TKKLITNLKP
HTFYNFVLMN RGNSMGGLQQ NVAAWTAANM LSRKPEVTHK PDADGNVVVI LPDVKSSVAV
QAYYIVVVPL RKSRGGQFLN PLGSPEEMDL EELVQDIARL RRRSLRHSRQ LDFPKPYIAA
RFRSLPNHFV LGDMKHYDNF ENRALEPGQR YVIFILAVLQ EPEATFAASP FSDPIQLDNP
DPQPIIDGEE GLIWVIGPVL AVVFIICIVI AILLYKNKRK DSEPRTKCLL NNAEITPHHP
KDPVEMRRIN FQTPDSGLSS PLSDPEFDFE SMLSHPPIPV SELAEHTEHL KANDNLKLSQ
EYESIDPGQQ FTWEHSNLEV NKPKNRYANV IAYDHSRVIL LPIEGIVGSD YINANYIDGY
RKQNAYIATQ GPLPETFGDF WRMVWEQRSA TIVMMTKLEE KSRIKCDQYW PGRGTDTYGM
IQVTLLDTIE LATFCVRTFS LHKNGSSEKR EVRQFQFTAW PDHGVPEYPT PFLAFLRRVK
TCNPPDAGPI VVHCSAGVGR TGCFIVIDAM LERIKHEKTV DIYGHVTLMR SQRNYMVQTE
DQYSFIHDAL LEAVACGNTE VPARNLYTYI QKLAQIEVGE HVTGMELEFK RLANSKAHTS
RFISANLPCN KFKNRLVNIM PYETTRVCLQ PIRGVEGSDY INASFIDGYR QQKAYIATQG
PLAETTEDFW RMLWENNSTI VVMLTKLREM GREKCHQYWP AERSARYQYF VVDPMAEYNM
PQYILREFKV TDARDGQSRT VRQFQFTDWP EQGVPKSGEG FIDFIGQVHK TKEQFGQDGP
ISVHCSAGVG RTGVFITLSI VLERMRYEGV VDIFQTVKML RTQRPAMVQT EDEYQFCYQA
ALEYLGSFDH YAT
//
