ID G3USP8_MELGA Unreviewed; 708 AA.
AC G3USP8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Fibrillin 2 {ECO:0008006|Google:ProtNLM};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000018726.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000018726.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000018726.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3USP8; -.
DR Ensembl; ENSMGAT00000020616.2; ENSMGAP00000018726.2; ENSMGAG00000010163.3.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_034268_0_0_1; -.
DR InParanoid; G3USP8; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000001645; Chromosome 30.
DR Bgee; ENSMGAG00000010163; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF3; FIBRILLIN 2; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 9.
DR Pfam; PF00683; TB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51364; TB; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 4..47
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 48..89
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 94..147
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 246..283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 288..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 368..410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 451..487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 708 AA; 77576 MW; BC6A6950C48FC4FA CRC64;
MCRDLDECAE GLHDCESRGM LCKNLIGTFM CICPPGMQRR PDGEGCTDEN ECRTKPGICP
NGRCINTVGS YRCDCNEGFE VSPSGTECID TRQGFCFTEV LQTMCQMSST NRNLVTKSEC
CCNSGRSWGP QCELCPLLGT AQYKKMCPHG PGYSTDGRGE LGLKSPLVQR GESRNVGKSR
TALGTVWGRS TQSLEQTSLY NIILQLPARN LWRSDKSWVA LAECSHRNMG IEAALALTAP
SLSPADIDEC KVLPNLCKNG QCINSIGSFR CHCRLGYTAD ITGTACVDLD ECNQSPKPCN
FICKNTDGSY QCSCPRGYVL QEDGKICKDL DECSTKQHNC QFLCVNVIGG FNCKCPPGFT
QHHSSCIDNN ECTAQPSLCG AKGQCLNTPG SYNCECQKGF SLDSSGVNCE DVDECDGNHR
CQHGCQNVLG GYRCGCPQGY VQHYQWNQCV DENECSSPTA CGSASCYNTL GSFKCVCPSG
FDFDQAFGGC QDVDECSAGG SPCSYGCSNT DGGYLCGCPG GYFRAGQGHC ISGLGFGKGS
YLPAPQEEDE DNLLSPETCY ECKINGYPKR GRQRRSVNGT ERHKDHTVNL ASMDVETPLS
MMLNLSDLAH NEHILELLPA VEPLENRVRY LISHGNEDGY FRIHQKEGLS FLHLGRKKIV
PGTYLLEIMS VPLYRKRELQ KLEAKNDLNY LAGELGQALR MKLQLQLY
//
