ID G3UTD8_MELGA Unreviewed; 1033 AA.
AC G3UTD8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 6 {ECO:0000313|Ensembl:ENSMGAP00000018981.2};
GN Name=KCNH6 {ECO:0000313|Ensembl:ENSMGAP00000018981.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000018981.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000018981.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000018981.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_010722790.1; XM_010724488.2.
DR AlphaFoldDB; G3UTD8; -.
DR Ensembl; ENSMGAT00000020078.2; ENSMGAP00000018981.2; ENSMGAG00000017356.2.
DR GeneID; 104914566; -.
DR CTD; 81033; -.
DR GeneTree; ENSGT00940000157790; -.
DR HOGENOM; CLU_005746_2_0_1; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000001645; Chromosome 29.
DR Bgee; ENSMGAG00000017356; Expressed in heart and 2 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF642; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 6; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 226..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..54
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 560..660
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 733..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 116775 MW; 1F15747D583412E0 CRC64;
MENCAIIYCN DGFCEMFGYS RVEVMQRPCT CDFLTGPDTT KSSIAQLTQA LLGSEECKLE
ILYYRKDTSC FRCLVDVVPV KNEDGVVIMF ILNFEDLAQL IAKSSGRSLH HRLSQSWRAE
ASHVKPNPPN STSDSDLMKY RTISQIPQFT LNFVEFNLEK HRSGSTTEIE IIAPHKVTER
TQNVTEKVTQ VLSLGADVLP EYKLQAPRIH RWTILHYSPF KAVWDWLILL LVIYTAVFTP
YSAAFLLNEE QVEEKHWNCS YSCDPLNIID LIVDIMFIVD IVINFRTTYV NINDEVVSHP
GKIAIHYFKG WFLIDMVAAI PFDLLIFRSG SDETTTLIGL LKTARLLRLV RVARKLDRYS
EYGAAVLFLL MCTFALIAHW LACIWYAIGN VERPYMEHKI GWLDNLGDQI GKRYNDSDLS
SGPSIKDKYV TALYFTFSSL TSVGFGNVSP NTNSEKIFSI CVMLIGSLMY ASIFGNVSAI
IQRLYSGTAR YHTQMLRVKE FIRFHQIPNP LRQRLEEYFQ HAWSYTNGID MNAVLKGFPD
CLQADICLHL NRTLLQNCKA FRGASKGCLR ALAMKFKTTH APPGDTLVHY GDVLTTLYFI
SRGSIEILKE DIVVAILGKN DIFGEPISLY ARPGKSNADV RALTYCDLHK IQREDLLEVL
DMYPAFSDNF WSNLEITFNL RDADSVPRTP LSEEYDCTYR RVRRRKHSLC QPNKPDPDTG
TSDAEQYHTY SELTNPQDPL SKDQWDDVGS STTPCSQTSD DEAKPGSPTK AEPFPLSKKD
DFALPALSLI TASASGTEVS KQAAESSQSY AATPLDIPNM FTFWEDQRPN HHPEPLQHVS
LVHSSRDIPL HSDYRPGQIE SRLELLQAQL SRLESRMSSD INIILQLLQR QLSQVPPAYS
PISPSSHNLA MYGIIPRSLE PLTPCAPLED EQRMAPGQSP SYTEVEKFHL KSRDSLSSGM
HLTVASDETM TVYSEQEHHS PPLPNPEPPN QRAPNTQGLL RGSRFPSLPE HLEASSEHPD
IQRHLSDPVL PGS
//
