GenomeNet

Database: UniProt
Entry: G3UV39_MELGA
LinkDB: G3UV39_MELGA
Original site: G3UV39_MELGA 
ID   G3UV39_MELGA            Unreviewed;       822 AA.
AC   G3UV39;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUN-2019, entry version 54.
DE   SubName: Full=ADAM metallopeptidase domain 22 {ECO:0000313|Ensembl:ENSMGAP00000019708};
GN   Name=ADAM22 {ECO:0000313|Ensembl:ENSMGAP00000019708};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000019708, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000019708, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000019708}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   Ensembl; ENSMGAT00000018293; ENSMGAP00000019708; ENSMGAG00000008341.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000156889; -.
DR   InParanoid; G3UV39; -.
DR   OMA; SWQGNIG; -.
DR   TreeFam; TF314733; -.
DR   Proteomes; UP000001645; Chromosome 6.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01421; Reprolysin; 2.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00429857};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    648    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    352       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      358    445       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      588    625       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      694    804       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3UV39}.
FT   COMPBIAS    697    721       Polar. {ECO:0000256|MobiDB-lite:G3UV39}.
FT   COMPBIAS    764    786       Polar. {ECO:0000256|MobiDB-lite:G3UV39}.
FT   DISULFID    417    437       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    615    624       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   822 AA;  91633 MW;  032DA5AA4335BCC7 CRC64;
     ICCLLNTLRG ISSKVERQWK LKEENIAIIR EKLEEIQYHL LPCQHATDYS KSAVPKKQKN
     DSELYENYNS DDDFHFHSVY KSKLFEFPLD DLPSEFWHVN ATSQKFVVKP RHKRRRRQVR
     QIPRKIEEET KYIELMIVND HLMCKKHRLS VGHTNSYAKS VVNLADLIYK EQLNTRIVLV
     AMETWATDNK FTISENPLVT LREFMKYRRD FIREKSDAVH LFSYVISCDG RWEELPGGTL
     VCLALGSRFQ SSRSGVAHTG GICSLLKGGG VNEFGKPDLM AVTLAQTLAQ NIGIFSDRRK
     LISGECKCED TWSGCIMGDT GYYLPSKFSK CDIEEYHEFL NNGGGACLFN KPTKLLDPPE
     CGNGFVEDGE ECDCGTTAEC ASEGGECCNT CTLTAGSQCS NGLCCRKCRF EPRGVLCREA
     VNDCDIAENC TGNSSQCSPN IHKMDGYSCD NRQGICFGGR CKTRDRQCKY IWGEKVSAAD
     RYCYEKLNIE GTEKGNCGRD KDSWVQCNKQ DVLCGYLLCS NISSVPRLGE LDGEITSSVL
     QFGKVYTCSG GHVKLDEETD LGYVENGTPC GPNMVCLDHR CLPIESFNFS TCPGTTDTQI
     CSGHGVCSNE IKCVCDRFWG GDDCSSRIKD DVFFYKDAIN KGVVSTNIII GAIAGTILVL
     ALVLGITAWG YKNMQKQIPQ GDYVKKPGEA DSFYSDMPPG VSTNSASSSK KRSNGLSHSW
     SERIPDTKHI SDICENGRPR SNSWQGNIGG NRKKVRGKRF RPRSNSTETL SPAKSPSSST
     GSIASSRKYP YPMPPLPDEE KKANRQSCAY GRLPFSCTVF LG
//
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