ID G3UVU2_MOUSE Unreviewed; 485 AA.
AC G3UVU2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Splicing factor 3a, subunit 2 {ECO:0000313|Ensembl:ENSMUSP00000117160.2};
GN Name=Sf3a2 {ECO:0000313|Ensembl:ENSMUSP00000117160.2,
GN ECO:0000313|MGI:MGI:104912};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117160.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000117160.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117160.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000117160.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117160.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SF3A2 family.
CC {ECO:0000256|ARBA:ARBA00008995}.
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DR RefSeq; NP_038679.3; NM_013651.4.
DR RefSeq; XP_006513457.1; XM_006513394.3.
DR RefSeq; XP_006513458.1; XM_006513395.3.
DR AlphaFoldDB; G3UVU2; -.
DR SMR; G3UVU2; -.
DR IntAct; G3UVU2; 1.
DR SwissPalm; G3UVU2; -.
DR EPD; G3UVU2; -.
DR MaxQB; G3UVU2; -.
DR PeptideAtlas; G3UVU2; -.
DR ProteomicsDB; 339425; -.
DR Antibodypedia; 22956; 182 antibodies from 24 providers.
DR DNASU; 20222; -.
DR Ensembl; ENSMUST00000148665.8; ENSMUSP00000117160.2; ENSMUSG00000020211.16.
DR GeneID; 20222; -.
DR KEGG; mmu:20222; -.
DR UCSC; uc011xiv.1; mouse.
DR AGR; MGI:104912; -.
DR CTD; 8175; -.
DR MGI; MGI:104912; Sf3a2.
DR VEuPathDB; HostDB:ENSMUSG00000020211; -.
DR GeneTree; ENSGT00720000108823; -.
DR HOGENOM; CLU_050757_1_1_1; -.
DR OMA; SREGMPH; -.
DR OrthoDB; 5475496at2759; -.
DR PhylomeDB; G3UVU2; -.
DR TreeFam; TF314370; -.
DR BioGRID-ORCS; 20222; 26 hits in 78 CRISPR screens.
DR ChiTaRS; Sf3a2; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000020211; Expressed in internal carotid artery and 264 other cell types or tissues.
DR ExpressionAtlas; G3UVU2; baseline and differential.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005686; C:U2 snRNP; IEA:Ensembl.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:1903241; P:U2-type prespliceosome assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.2690; -; 1.
DR InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR031781; SF3A2_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23205; SPLICING FACTOR 3A SUBUNIT 2; 1.
DR PANTHER; PTHR23205:SF0; SPLICING FACTOR 3A SUBUNIT 2; 1.
DR Pfam; PF16835; SF3A2; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM01050; CactinC_cactus; 1.
DR SMART; SM00451; ZnF_U1; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS50171; ZF_MATRIN; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:G3UVU2,
KW ECO:0007829|MaxQB:G3UVU2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 54..84
FT /note="Matrin-type"
FT /evidence="ECO:0000259|PROSITE:PS50171"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 51279 MW; 70D2CAE4FC938458 CRC64;
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL
TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT
KQRDTEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA
FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG
LPPRPPLPDA LPPPPPGGLP LPPMPPTGPA PSGPPGPPQM PPPAPGVHPP APVVHPPTSG
VHPPAPGVHP PAPVVHPPTS GVHPPAPGVH PPTPGVHPPA PGVHPPAPGV HPPAPGVHPP
TPGVHPPAPG VHPPAPGVHP PAPGVHPPPS AGVHPQAPGV HPPAPAVHPQ APGVHPPAPG
IHPQAPGVHP QPPPGVHPAA PGVHPQPPGV HPSNPGVHPA PMPPMLRPPL PSDGPGNMPP
PPPGN
//
