ID G3UZT4_MOUSE Unreviewed; 181 AA.
AC G3UZT4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Huntingtin-associated protein 1 {ECO:0000313|Ensembl:ENSMUSP00000134625.2};
DE Flags: Fragment;
GN Name=Hap1 {ECO:0000313|Ensembl:ENSMUSP00000134625.2,
GN ECO:0000313|MGI:MGI:1261831};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134625.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000134625.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134625.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000134625.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134625.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
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DR AlphaFoldDB; G3UZT4; -.
DR SMR; G3UZT4; -.
DR MaxQB; G3UZT4; -.
DR ProteomicsDB; 316072; -.
DR Antibodypedia; 80380; 282 antibodies from 35 providers.
DR Ensembl; ENSMUST00000146878.3; ENSMUSP00000134625.2; ENSMUSG00000006930.16.
DR AGR; MGI:1261831; -.
DR MGI; MGI:1261831; Hap1.
DR VEuPathDB; HostDB:ENSMUSG00000006930; -.
DR GeneTree; ENSGT00940000162183; -.
DR HOGENOM; CLU_1492405_0_0_1; -.
DR OMA; RNYEVTP; -.
DR ChiTaRS; Hap1; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000006930; Expressed in dorsomedial nucleus of hypothalamus and 189 other cell types or tissues.
DR ExpressionAtlas; G3UZT4; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR InterPro; IPR006933; HAP1_N.
DR PANTHER; PTHR15751:SF14; HUNTINGTIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR15751; TRAFFICKING KINESIN-BINDING PROTEIN; 1.
DR Pfam; PF04849; HAP1_N; 1.
DR SMART; SM01424; HAP1_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Proteomics identification {ECO:0007829|MaxQB:G3UZT4,
KW ECO:0007829|ProteomicsDB:G3UZT4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..180
FT /note="HAP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01424"
FT REGION 64..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..149
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 64..88
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 181
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000134625.2"
SQ SEQUENCE 181 AA; 21176 MW; D16CC78CC67D8062 CRC64;
MLYLLEEKER DLNTAARIGQ SLVKQNSVLM EENNKLETML GSAREEILHL RKQVNLRDDL
LQLYSDSDDD DDEEDEEDEE EGEEEEREGQ RDQDQQHDHP YGAPKPHPKA ETAHRCPQLE
TLQQKLRLLE EENDHLREEA SHLDNLEDEE QMLILECVEQ FSEASQQMAE LSEVLVLRLE
G
//
