ID G3UZW0_MOUSE Unreviewed; 255 AA.
AC G3UZW0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Slit guidance ligand 2 {ECO:0000313|Ensembl:ENSMUSP00000134655.3};
DE Flags: Fragment;
GN Name=Slit2 {ECO:0000313|Ensembl:ENSMUSP00000134655.3,
GN ECO:0000313|MGI:MGI:1315205};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134655.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000134655.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134655.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000134655.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134655.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3UZW0; -.
DR SMR; G3UZW0; -.
DR PeptideAtlas; G3UZW0; -.
DR ProteomicsDB; 355725; -.
DR Antibodypedia; 3487; 353 antibodies from 40 providers.
DR Ensembl; ENSMUST00000172493.3; ENSMUSP00000134655.3; ENSMUSG00000031558.16.
DR UCSC; uc008xjr.1; mouse.
DR AGR; MGI:1315205; -.
DR MGI; MGI:1315205; Slit2.
DR VEuPathDB; HostDB:ENSMUSG00000031558; -.
DR GeneTree; ENSGT00940000158402; -.
DR HOGENOM; CLU_1092110_0_0_1; -.
DR ChiTaRS; Slit2; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000031558; Expressed in metanephric ureteric bud and 311 other cell types or tissues.
DR ExpressionAtlas; G3UZW0; baseline and differential.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF2; SLIT HOMOLOG 2 PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51450; LRR; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|MaxQB:G3UZW0,
KW ECO:0007829|PeptideAtlas:G3UZW0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 175..210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 241..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000134655.3"
FT NON_TER 255
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000134655.3"
SQ SEQUENCE 255 AA; 28023 MW; 3B048180A4B0F53F CRC64;
TELYLDGNQF TLVPKELSNY KHLTLIDLSN NRISTLSNQS FSNMTQLLTL ILSYNRLRCI
PPRTFDGLKS LRLLSLHGND ISVVPEGAFN DLSALSHLAI GANPLYCDCN MQWLSDWVKS
EYKEPGIARC AGPGEMADKL LLTTPSKKFT CQELPGPCGF LIPGPVDITI QAKCNPCLSN
PCKNDGTCNN DPVDFYRCTC PYGFKGQDCD VPIHACISNP CKHGGTCHLK EGENAGFWCT
CADGFEGENC EVNID
//
