ID G3V595_HUMAN Unreviewed; 305 AA.
AC G3V595;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Serpin family A member 3 {ECO:0000313|Ensembl:ENSP00000452246.3};
DE Flags: Fragment;
GN Name=SERPINA3 {ECO:0000313|Ensembl:ENSP00000452246.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452246.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000452246.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000452246.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; AL049839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3V595; -.
DR SMR; G3V595; -.
DR EPD; G3V595; -.
DR MassIVE; G3V595; -.
DR MaxQB; G3V595; -.
DR PeptideAtlas; G3V595; -.
DR PRIDE; G3V595; -.
DR ProteomicsDB; 33460; -.
DR Antibodypedia; 765; 705 antibodies from 39 providers.
DR Ensembl; ENST00000555820.1; ENSP00000452246.3; ENSG00000196136.18.
DR UCSC; uc059etl.1; human.
DR HGNC; HGNC:16; SERPINA3.
DR VEuPathDB; HostDB:ENSG00000196136; -.
DR GeneTree; ENSGT00940000154392; -.
DR OMA; MFVEEQL; -.
DR ChiTaRS; SERPINA3; human.
DR Proteomes; UP000005640; Chromosome 14.
DR Bgee; ENSG00000196136; Expressed in right lobe of liver and 95 other cell types or tissues.
DR ExpressionAtlas; G3V595; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF145; ALPHA-1-ANTICHYMOTRYPSIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:G3V595,
KW ECO:0007829|MaxQB:G3V595};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..305
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003457330"
FT DOMAIN 58..305
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT NON_TER 305
FT /evidence="ECO:0000313|Ensembl:ENSP00000452246.3"
SQ SEQUENCE 305 AA; 34626 MW; 6517450DCC883000 CRC64;
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL
YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ
HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI
NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM
VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR
DSLEF
//
