ID G3V6C0_RAT Unreviewed; 1156 AA.
AC G3V6C0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Class II, major histocompatibility complex, transactivator {ECO:0000313|Ensembl:ENSRNOP00000003572.3};
GN Name=Ciita {ECO:0000313|Ensembl:ENSRNOP00000003572.3,
GN ECO:0000313|RGD:619813};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000003572.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000003572.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003572.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000003572.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003572.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3V6C0; -.
DR STRING; 10116.ENSRNOP00000003572; -.
DR PaxDb; 10116-ENSRNOP00000003572; -.
DR Ensembl; ENSRNOT00000003572.4; ENSRNOP00000003572.3; ENSRNOG00000002659.7.
DR AGR; RGD:619813; -.
DR RGD; 619813; Ciita.
DR VEuPathDB; HostDB:ENSRNOG00000002659; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000161578; -.
DR InParanoid; G3V6C0; -.
DR OMA; PFAFPRH; -.
DR OrthoDB; 5311112at2759; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002659; Expressed in spleen and 16 other cell types or tissues.
DR ExpressionAtlas; G3V6C0; baseline and differential.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:RGD.
DR GO; GO:0071257; P:cellular response to electrical stimulus; IEP:RGD.
DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEP:RGD.
DR GO; GO:0071346; P:cellular response to type II interferon; IEP:RGD.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0046597; P:negative regulation of viral entry into host cell; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD.
DR GO; GO:0045345; P:positive regulation of MHC class I biosynthetic process; ISO:RGD.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IDA:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0046677; P:response to antibiotic; ISO:RGD.
DR GO; GO:0034341; P:response to type II interferon; ISO:RGD.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR008095; MHC_II_transact.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47189; MHC CLASS II TRANSACTIVATOR; 1.
DR PANTHER; PTHR47189:SF1; MHC CLASS II TRANSACTIVATOR; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR PRINTS; PR01719; MHCIIACTVATR.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 443..589
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 203..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 127324 MW; 6B4D90CBF3E0DB5D CRC64;
MNHFQAILAQ VQTLLSSQQP RQVRALLDGL LEEELLSREY HCALLHEPDG EALARKISLT
LLEKGDLDLA FVSWVCNRLQ VPEVERGPNC RDHGGHTLCA TMELGSPEGS YLELLNSDAD
PLHLYHLYDQ MDLAGEEEIE LNSETDMDTI NCDQFSKLLQ DMEMDEETRE AYANIAELDQ
YVFQDTQLEG LSKDLFIQHI GPEEGFGENV EGPAESGEKP QKRREKMGAV GNSTSLPLSP
SVPPSRTSLN YLDLPAGHIQ IFTTLPQGLW QISGVGTGLS SVLVYHGEMP QVNQLLSSSS
PTVPSLPESP DRPGSTSPFA PSTADLPGMP EPALTSRVNE TEDTTPPSPC QEDPEPSIKL
PKWPESVERF QHSLQDKYQA LPGSPSGPLV AMELVRARLE RGSNKSQERE LATPDWTERQ
LAHGGLAEVL RVVGDSRRSR ETQVVAVLGK AGQGKSHWAR TVSHIWAQGQ LPQYDFVFYV
PCQCLDRPGD TYHLRDLLCP PNLQPLAMDD EVIDHIVRQP DRVLLILDAF EELEAQDSLL
HGPCGPLSPE PCSLRGLLAG LFQRKLLRGC TLLLTARPRG RLAQSLSKAD AIFEVPSFST
KQAQIYMRHY FENSGTAGSH DKALGLLEGQ PFLLTHSHSP VLCSAVCQLS KALLDQGAEA
QLPCTLTGLY VGLLGPAAQN SPPGALVELA KLAWELGRRH QSTLQETQFP SVEVKTWAVA
QGLMQQTTEA QLAFSSFLLQ CFLGAVWLAQ CNEMKDKELP QYLALTPRKK RPYDNWLEGV
PRFLAGLVFQ PRAHCLGALV EPAMAAVADR KRKVLTRYLK RLKLGTLRAG RLLELLHCAH
ETQEPGIWKH VSHQLPGHLS FLGTRLTAPD VYVLGRALET ASQDFSLDLR QTGIEPSRLG
DLVGLSCVTS FRASLSDTMA LWESLQHQGE TQLLQAAEEK FTIEPFKAKS PKDVEDLDSL
VQTQRLRNPS ADAAKDLPAI RDLKKLEFAL GPVLGPQAFP TLAKILPAFS SLQHLDLDSL
SENKIGDKGV SKLSATFPQL KALETLNLSQ NSITDVGACK LAEALPALAK SLLRLSLYNN
CICDEGAKSL ARVLPDMVSL RVMDVQFNKF TAVGAQQLTS SLQKCPQVET LAMWTPTIPF
GVQEHLQQLD ARISLR
//
