ID G3V6X1_RAT Unreviewed; 1222 AA.
AC G3V6X1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Fibulin 2 {ECO:0000313|Ensembl:ENSRNOP00000009696.6};
GN Name=Fbln2 {ECO:0000313|Ensembl:ENSRNOP00000009696.6,
GN ECO:0000313|RGD:628685};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000009696.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000009696.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009696.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000009696.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009696.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3V6X1; -.
DR STRING; 10116.ENSRNOP00000009696; -.
DR iPTMnet; G3V6X1; -.
DR PhosphoSitePlus; G3V6X1; -.
DR PaxDb; 10116-ENSRNOP00000009696; -.
DR Ensembl; ENSRNOT00000009696.8; ENSRNOP00000009696.6; ENSRNOG00000007338.9.
DR AGR; RGD:628685; -.
DR RGD; 628685; Fbln2.
DR VEuPathDB; HostDB:ENSRNOG00000007338; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000156047; -.
DR HOGENOM; CLU_268948_0_0_1; -.
DR InParanoid; G3V6X1; -.
DR OMA; MNTCRDI; -.
DR OrthoDB; 19806at2759; -.
DR TreeFam; TF317514; -.
DR Reactome; R-RNO-2129379; Molecules associated with elastic fibres.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000007338; Expressed in esophagus and 20 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050840; F:extracellular matrix binding; ISO:RGD.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISO:RGD.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd00054; EGF_CA; 8.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF01821; ANATO; 2.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF14670; FXa_inhibition; 1.
DR SMART; SM00104; ANATO; 3.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1222
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035312392"
FT DOMAIN 436..471
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 479..510
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 512..544
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 595..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 896..938
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 939..980
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 274..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 131403 MW; BDED3867859F511F CRC64;
TMLLQESAGV WLALALVTAL TLSPSMGVPW QDCTGAECPP LENCIEEALE PGACCATCVQ
QGCACEGYQY YDCVQGGFVD GRVPAGQSYF VDFGSTECSC PPGGGKISCQ FMLCPELPPN
CIEAVVVADS CPQCGQVGCV HSGRKYAAGH TVHLSSCRAC HCPDAGGELI CYQLPGCHGN
FSDAEEGDSE RQYEDPYSYD QEVAEAEATV AIVNEVQAGA EGPPAALGGG NLPPSSIRVT
PWPVALPRPT AAAALGPPAP VQAKARRVTL DIDEEEEEEV EEILATEPPV AGSPGRLDSL
PTTSPARPGL PVQEKEAEAK AGPEENLIPE AQATSRSVTQ EGAAPLPKSG LAGLSPSLAT
DSSSEDALKS SSQPTLSTLP PDRAQVSPSP ETPEEIPQRP QLLPRSRAEE DTDPNSVHSV
PRGDPDGSTK DLVETCCAAG QQWAIDNDEC QEIPENGAQS DVCRIAQRHC CISYLKEKSC
VAGVMGAKEG ETCGAEDNDT CGVSLYKQCC DCCGLGLRVR AEGQSCESNP NLGYPCSHVM
LSCCEGEEPL IVPEVRRPPE PGATPRRVSE TEMGSREALS LGTEAELPNS LPGDDQDECL
MLPGELCQHL CINTVGSYRC ACFPGFELQG DGRTCRPDGG APQLDTARES APRSESAQVS
PNTIPLPVPQ PNTCKDNGPC RQVCRVIGDT AMCSCFPGYA IMADGVSCED QDECLMGTHD
CSWKQFCVNT LGSFYCVNHT VLCAEGYILN AHRKCVDINE CVTDLHTCTR AEHCVNTPGS
FQCYKALTCE PGYVLTDGEC TDVDECVTGT HNCQAGFSCQ NTKGSFYCQA RQRCMDGFLQ
DPEGNCVDIN ECTSLLEPCR SGFSCINTVG SYTCQRNPLV CRRGYHANEE GSECVDVNEC
ETGVHRCGEG QLCYNLPGSY RCDCKPGFQR DAFGRTCIDV NECWISPGRL CQHTCENTPG
SYRCSCAAGF LLAADGKHCE DVNECETRRC SQECANIYGS YQCYCRQGYQ LAEDGHTCTD
IDECAQGAGI LCTFRCVNVP GSYQCACPEQ GYTMMANGRS CKDLDECALG THNCSEAETC
HNIQGSFRCL RFDCPPNYVR VSETKCERTT CQDISECQTS PARITHYQLN FQTGLLVPAH
IFRIGPAPAF AGDTISLTIT KGNEEGYFVT RRLNAYTGVV SLQRSVLEPR DFALDVEMKL
WRQGSVTTFL AKMYIFFTTV AP
//
