ID G3V830_RAT Unreviewed; 569 AA.
AC G3V830;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE SubName: Full=Interleukin 10 receptor subunit alpha {ECO:0000313|Ensembl:ENSRNOP00000021926.1};
GN Name=Il10ra {ECO:0000313|Ensembl:ENSRNOP00000021926.1,
GN ECO:0000313|RGD:620138};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000021926.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000021926.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021926.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000021926.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021926.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_476541.2; NM_057193.2.
DR RefSeq; XP_006242926.1; XM_006242864.3.
DR AlphaFoldDB; G3V830; -.
DR SMR; G3V830; -.
DR STRING; 10116.ENSRNOP00000021926; -.
DR PaxDb; 10116-ENSRNOP00000021926; -.
DR Ensembl; ENSRNOT00000021926.5; ENSRNOP00000021926.1; ENSRNOG00000016308.5.
DR GeneID; 117539; -.
DR KEGG; rno:117539; -.
DR AGR; RGD:620138; -.
DR CTD; 3587; -.
DR RGD; 620138; Il10ra.
DR eggNOG; ENOG502S2PS; Eukaryota.
DR GeneTree; ENSGT00510000048847; -.
DR HOGENOM; CLU_033904_0_0_1; -.
DR OMA; TGQWNQP; -.
DR OrthoDB; 5347858at2759; -.
DR TreeFam; TF334107; -.
DR Reactome; R-RNO-6783783; Interleukin-10 signaling.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000016308; Expressed in spleen and 18 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0019969; F:interleukin-10 binding; IMP:RGD.
DR GO; GO:0004920; F:interleukin-10 receptor activity; IMP:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0060729; P:intestinal epithelial structure maintenance; ISO:RGD.
DR GO; GO:0010507; P:negative regulation of autophagy; ISO:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:RGD.
DR GO; GO:0050807; P:regulation of synapse organization; IMP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; ISO:RGD.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF53; INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 7..113
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
SQ SEQUENCE 569 AA; 63444 MW; 112C61962C4F79D7 CRC64;
MLPRLLPFLV SISSLSLGFR AHGTELPSPS SVWFEARFFQ HILRWMSIPN QSESTYYEVA
LKKYGTSVWK DIHICSKAQT LSCDLTTSTL DLYHSSGYRA RVRAVDNSQY SNWTITETRF
TVDEVILTVD SVTLKVSNGF IYGTIHPPRP NLVPVGDEYE QIFTHHRIYR VCIRKFSEQK
NITKTVEQEN FTLEVPKGMR KFCVKVMPHV ESRINKAEWS EEQCLHVTTE HYFTVTNLSI
FFLSILILCG ALVCLVLLWY IRHPGKLPAV LVFEKPPDFL LANPRCPETL DDIHILDLEA
FPKVSPELKD SDLHGSTDSG FGSGKPSLQT EESQFFLLDS HAQIQETLGK EGSSELQDTC
GDNTDSGICL QESSLHSSMG PPWKQQFGYT HQDQDDSDLV QNSPGHPKHT QDGSALGHGC
LLEPEVPEEK DQVMVTFQGY QKQTRWKEEA AEPLDGEIPL AEAFDPELGV RLQGDSAWPP
VALATGYLKQ ESQGMASAPP GTPSRQWNQL AEECSLLGVV SCEDLSIESL GFAHELVPLD
CGAASSGLLD SLGTNLVTLP LISSLQIEE
//