ID G3V863_RAT Unreviewed; 238 AA.
AC G3V863; O08627;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Prolactin family 8, subfamily A, member 4 {ECO:0000313|Ensembl:ENSRNOP00000022614.3};
DE SubName: Full=Prolactin-like protein-C variant {ECO:0000313|EMBL:AAB51593.1};
GN Name=Prl8a3 {ECO:0000313|RGD:3406};
GN Synonyms=Prl8a4 {ECO:0000313|Ensembl:ENSRNOP00000022614.3,
GN ECO:0000313|RGD:620116}, Prlpc1 {ECO:0000313|RGD:3406};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000022614.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|EMBL:AAB51593.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar Kyoto {ECO:0000313|EMBL:AAB51593.1};
RC TISSUE=Liver {ECO:0000313|EMBL:AAB51593.1};
RX PubMed=8895375; DOI=10.1210/en.137.11.5009;
RA Dai G., Liu B., Szpirer C., Levan G., Kwok S.C., Soares M.J.;
RT "Prolactin-like protein-C variant: complementary deoxyribonucleic acid,
RT unique six exon gene structure, and trophoblast cell-specific expression.";
RL Endocrinology 137:5009-5019(1996).
RN [2] {ECO:0000313|EMBL:AAB51593.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar Kyoto {ECO:0000313|EMBL:AAB51593.1};
RC TISSUE=Liver {ECO:0000313|EMBL:AAB51593.1};
RA Dai G., Soares M.J.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000022614.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022614.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000022614.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022614.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000256|ARBA:ARBA00008474}.
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DR EMBL; U93351; AAB51593.1; -; mRNA.
DR RefSeq; NP_064464.1; NM_020079.1.
DR Ensembl; ENSRNOT00000022614.5; ENSRNOP00000022614.3; ENSRNOG00000016803.6.
DR GeneID; 100361884; -.
DR KEGG; rno:100361884; -.
DR AGR; RGD:3406; -.
DR CTD; 100361884; -.
DR RGD; 3406; Prl8a3.
DR RGD; 620116; Prl8a4.
DR VEuPathDB; HostDB:ENSRNOG00000016803; -.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_0_1_1; -.
DR OMA; QPHFYAL; -.
DR OrthoDB; 4787867at2759; -.
DR TreeFam; TF332592; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000016803; Expressed in liver.
DR Genevisible; O08627; RN.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd10288; prolactin_like; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417:SF69; PROLACTIN-8A6-RELATED; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..238
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197699"
SQ SEQUENCE 238 AA; 27219 MW; 45D9AAB343BF453E CRC64;
MELALTQPPF FGTLLMLVVS NLLLWEKAAS IPACMVEDGG CWDPLEETVN SAIQKAENLR
NLAHHLYVEF YQNQFSSRQF ADLNSQLMRW DETVVKTGTY CHSTLARPQN KGINIEIEVY
LQTLINFVGS WISPLLHLVI ELSAMEGVPE TILSKAKDLE ENNRQLLDDL RWILTKVSPT
AEMKEEFPSW GYLSFLKSSS KNHKFLAVFN LSNCLEDDTK FTLYHLRILK CLITGKDC
//
