ID G3V8B1_RAT Unreviewed; 843 AA.
AC G3V8B1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D {ECO:0000256|ARBA:ARBA00015988};
DE EC=3.1.4.50 {ECO:0000256|ARBA:ARBA00012284};
DE AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D {ECO:0000256|ARBA:ARBA00029753};
GN Name=Gpld1 {ECO:0000313|Ensembl:ENSRNOP00000024196.2,
GN ECO:0000313|RGD:631371};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000024196.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000024196.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000024196.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000024196.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000024196.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-
CC myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a
CC 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997,
CC ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50;
CC Evidence={ECO:0000256|ARBA:ARBA00034002};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GPLD1 family.
CC {ECO:0000256|ARBA:ARBA00008652}.
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DR RefSeq; NP_001093982.1; NM_001100512.1.
DR RefSeq; XP_006253985.1; XM_006253923.3.
DR RefSeq; XP_008769848.1; XM_008771626.2.
DR RefSeq; XP_008769850.1; XM_008771628.2.
DR RefSeq; XP_008769851.1; XM_008771629.2.
DR RefSeq; XP_008769853.1; XM_008771631.2.
DR RefSeq; XP_017455969.1; XM_017600480.1.
DR RefSeq; XP_017455970.1; XM_017600481.1.
DR RefSeq; XP_017455971.1; XM_017600482.1.
DR RefSeq; XP_017455972.1; XM_017600483.1.
DR RefSeq; XP_017455973.1; XM_017600484.1.
DR AlphaFoldDB; G3V8B1; -.
DR Ensembl; ENSRNOT00000024196.4; ENSRNOP00000024196.2; ENSRNOG00000017702.4.
DR GeneID; 291132; -.
DR KEGG; rno:291132; -.
DR CTD; 2822; -.
DR RGD; 631371; Gpld1.
DR GeneTree; ENSGT00390000013522; -.
DR HOGENOM; CLU_011756_0_0_1; -.
DR OMA; CGMTTHN; -.
DR OrthoDB; 1332649at2759; -.
DR TreeFam; TF335726; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000017702; Expressed in liver and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0071397; P:cellular response to cholesterol; IEA:Ensembl.
DR GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR GO; GO:0071401; P:cellular response to triglyceride; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0006507; P:GPI anchor release; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR001028; Gprt_PLipase_D.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR029002; PLPC/GPLD1.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF01839; FG-GAP; 4.
DR Pfam; PF00882; Zn_dep_PLPC; 1.
DR PRINTS; PR00718; PHPHLIPASED.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 28..207
FT /note="Phospholipase C/D"
FT /evidence="ECO:0000259|Pfam:PF00882"
SQ SEQUENCE 843 AA; 93667 MW; A15C8DCB9EA2828F CRC64;
MSVGRLWSGL LLLLLFFCSR SSSCGLSTHV EIGHRALQFL QLQDGRINYK ELLLEHQDAY
QAGTVFPDAF YPSICKQGKF HEVSESTHWT PFLNASIHYI RENYPLPWEK DTEKLVAFLF
GVTSHMVADV SWHSLGIEQG FLRTMGAIDF YDSYSEAHSA GDFGGDVLSQ FEFNFNYLSR
RWYVPIQDLL RIYDNLYGRK VITKNVIVDC TYLQFLEMHG EMLAVSKLYS TYSTKSPFLV
EQFQDYFLGG LDDMAFWSTN IYRLTSFMLE NGTSDCNLPE NPLFISCDGR KNHTLSSSKV
QKNDFHRNLT MFISKDIRKN LNYTERGVFY STGSWAPESV TFMYQTLERN LRMMFTGNSQ
TALKHVSSPS ASYTLSVPYA RLGWVMASAD LNQDGHGDLV VGAPGYSHPG RFQIGRVYII
YGNDLGLPPI DLDLDKEAHG VLEGFQPSGR FGSALAVLDF NKDGLPDLAV GAPSVGSGQL
TYNGSVYVYY GSQQGRLSSS PNITISCKDT YCNLGWALLA ADADGDGQHD LVISSPFAPG
GGKQRGIVAA FYSHPRRNDK ESLTLDEADW KVNGEEDFSW FGYSLHGVTV ANRSLLLIGS
PTWKNISRMA RSSHQKNQEK KSLGRVYGYF PPNRQREITI SGDKAMGKLG TSLSSGYVRV
NGTLTQVLLV GAPTHDDVSK MAFLTMTLHQ GGATRMYELA PEKTQPALLS TFSGDRRFSR
FGSVLHLTDL DDDGLDEIIM AAPLRITDVT SGLLGGEDGR VYIYNGMHTT LGDVTGKCKS
WMTPCPEEKA QYVLISPEAS SRFGSSLVSV RSKERNQVVV AAGRSSWGAR LSGALHVYSF
SSD
//
