ID G3VA36_SARHA Unreviewed; 678 AA.
AC G3VA36;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN Name=CHUK {ECO:0000313|Ensembl:ENSSHAP00000000040.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000040.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000040.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000040.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3VA36; -.
DR Ensembl; ENSSHAT00000000042.2; ENSSHAP00000000040.2; ENSSHAG00000000038.2.
DR GeneTree; ENSGT00950000182937; -.
DR HOGENOM; CLU_000288_101_2_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProt.
DR CDD; cd17046; Ubl_IKKA_like; 1.
DR Gene3D; 1.20.1270.250; -; 1.
DR Gene3D; 6.10.250.2110; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR InterPro; IPR022007; IKKbetaNEMObind.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
DR Pfam; PF12179; IKKbetaNEMObind; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM01239; IKKbetaNEMObind; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..232
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 678 AA; 77166 MW; 1874D10F54F0D816 CRC64;
MDRPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELGNK IAIKSCRLEL SAKNKDRWCH
EIQIMKNYST NQRIAVDLKR VKSFLYLVIL IIHKIIDLGY AKDLDQGSLC TSFVGTLQYL
APELFENKPY TATVDYWSFG TMVFECIVGY RPFLHHLQPF TWHEKIKKKD PKHIFAFEEM
TGEVRFSSHL PQPNSLSSFI VEPMEQWLQL MLTWDPQQRG GSLDLTLKQP GCFVLMDQIL
NLKIAHILNM TSAKIISFLL LPEESFHSLQ SRIEQETGIS TASQELLLEM GISLDPRKPA
SQCVLDGVRG CDSYMVYLFD KSKIVYEGPF ASRSLSECVN YIVKDSKIQL PVMQLRRVWA
EAVHYVSGLK EDYSRLFQGQ RAAMLSLLRY NANLTKMKNT MISASQQLKA KLQFFHQSIQ
LDLDRYSDQM TYGISSEKML KAWKEMEEKA IQCAQAGDIG YLDEQIMSLH TEIVELQRSP
SARRQEDVME SLEQKAIDLY KQLKPRSPDH SYSDSSEMVK IIVLTVQNQD RVLKELFGHL
SKLLGCKQKI IDLLPKIEVA LNNIKEADNT VMLMQGKRQR EIWHLLKIAC TQSSARSLVG
TSLEGAVTTP TPAGLPSTLT APVPRSLACV LNAQDGETFT QIVEENLNYL GCLSTVIREA
TEEQGKSLMS LDWSWLKQ
//
