ID G3VAR8_SARHA Unreviewed; 1260 AA.
AC G3VAR8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN Name=IARS1 {ECO:0000313|Ensembl:ENSSHAP00000000272.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000000272.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000000272.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000000272.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3VAR8; -.
DR STRING; 9305.ENSSHAP00000000272; -.
DR Ensembl; ENSSHAT00000000277.2; ENSSHAP00000000272.2; ENSSHAG00000000237.2.
DR eggNOG; KOG0434; Eukaryota.
DR GeneTree; ENSGT00550000074921; -.
DR HOGENOM; CLU_001493_1_1_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR CDD; cd00818; IleRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 17..638
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 692..848
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1260 AA; 143664 MW; A24D693002F4B3CB CRC64;
MVQPVPETIS FPDEEEKILE FWTRFSCFRE CLKQSKSRPR FTFYDGPPFA TGLPHYGHIL
AGTIKDVVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIKGPEDVAK MGIAEYNRQC
RGIVMRYAAE WKVTISRLGR WIDFENDYKT LYPQFMESVW WVFRQLYDKG LVYRGVKVMP
FSTACNTPLS NFESHQNYKD VQDPSVFVTF PLEEDEAVSL VAWTTTPWTL PSNLALCVNP
DLQYVKLRDA ATGRVLIMME ARLVALYKSE SDYVILERFP GISLKGKRYK PMFEYFVKCR
ENGAFTVLVD HYVKEEEGTG VVHQAPYFGA DDYRVCMDSN IIQKDSVPVC PVDASGCFTA
DVSDFAGQYV KDADKNIIRA IKEQGRLLLA GTFNHNYPFC WRSDTPLIYK AVPSWFVRVE
HMVDRLLENN DQCYWVPEFV REKRFGNWLK DARDWAISRN RYWGTPIPLW VSDDFEEVVC
IGSVSELEEL TGAKVSDLHR ESIDHLTIPS RLGKGPLRRV AEVFDCWFES GSMPYAQVHY
PFESRREFEE AFPADFIAEG IDQTRGWFYT LLVLATALFG KPPFKNVIVN GLILASDGQK
MSKRKKNYPD PTSVISKYGA DALRLYLINS PVVRAENLRF KEEGVRDVLK DVLLPWYNVY
RFLIQNILRL RKEGVEFLYN ENAVRESGNI TDRWILSFMQ SLIGFFEVEM AAYRLYTVVP
RLVKFVDVLT NWYVRMNRRR LKGENGTDDC VMALETLFSI LFSLCKLMAP YTPFLTELIY
QNLKTLIDPA SVREKDTLSI HYLMLPRVRE ELIDKKTENA VSRMQSVIEL GRVIRDRKTI
PIKYPLKEIV VIHQDPEALN DIRSLEKYIL EELNVRRVTL STDKNKYGIR LRAEPDHMVL
GKRLKAAFKA MMASIKELTN EQLEHLQQTG SLIVGGHELH REDVRLLYTF DQAQGSSSQY
EAHSDAQVLV LLDVTPDQSM VDEGMAREVI NRIQKLRKKC NLVPTDEVAV YYRSPSQGDY
LDTVIQSHTD FILATIKAPL KPYPVPPSDK VLIQEVTQLK GSDLEITLTR GASPPAPACA
YVNLNVCVNG KERGGVLLLE NPKGDHRLDL AQLKGAIGSI FGLRAPELAV FHEKTEVVSK
TDLLSLSGKT LCVTSGPPPA AAPSPSVLCG FLNLQLLNAK PQECLAGQVG TLLLENPLGQ
KPLTYQGLLH EAAKVFGLRS RRLRLFLNAA QTQEIPADVS MKSLNMRTVY VDVLPTTAEC
//