ID G3VCX5_SARHA Unreviewed; 1734 AA.
AC G3VCX5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSSHAP00000001029.2};
GN Name=ARFGEF2 {ECO:0000313|Ensembl:ENSSHAP00000001029.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000001029.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000001029.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000001029.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR Ensembl; ENSSHAT00000001043.2; ENSSHAP00000001029.2; ENSSHAG00000010317.2.
DR GeneTree; ENSGT00940000158950; -.
DR HOGENOM; CLU_000691_1_2_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF124; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 605..794
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 224..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1734 AA; 197019 MW; 3AC6E3B578E60FE9 CRC64;
MQESQTKSMF VSRALEKILA DKEAKRPQHS QLRRACQVAL GEPLPALPPK ANFIEADKYF
LPFELACQSK SPRVVSTSLD CLQKLIAYGH ITGNAPDSGA PGKRLIDRIV ETVCNCFQGP
QTDEGVQLQI IKALLTAVTS PHIEIHEGTI LQTVRTCYNI YLASKNLINQ TTAKATLTQM
LNVIFTRMEN QALQEARELE KTMHPKPQSP VLQAMAGSPK LNQLKHNQLP SKTSTPEKTG
LTNGEHQRRG SHEDRIENGE AQLEGGPALS GMFWVVCFLI VLKRNLLFEG KIRYHSKIYF
MSKIPWNSGK YYLSSSFESD VHGPQVAAKF SHILQKDAFL VFRSLCKLSM KPLGEGPPDP
KSHELRSKVV SLQLLLSVLQ NAGPVFRTHE MFINAIKQYL CVALSKNGVS SVPDVFELSL
AIFLTLLSNF KTHLKMQIEV FFKEIFLNIL ETSTSSFEHK WMVIQTLTRI CADAQCVVDI
YVNYDCDLNA ANIFERLVND LSKIAQGRSG HELGMTPLQE LSLRKKGLEC LVSILKCMVE
WSKDLYVNPN HQTSLGQERS TDQDLGEPKG LDIRRRSSVS SMDSTMSSGI GSVGTQTSVP
DDPEQFEVIK QQKEIIEHGI ELFNKKPKRG IQYLQEQGML GTPVEDIAQF LHQEERLDST
QVGDFLGEST RLNKEVMYAY VDQLDFCGKD FVSALRIFLE GFRLPGEAQK IDRLMEKFAA
RYLECNQGQT MFASADTAYV LAYSIIMLTT DLHSPQVKNK MTKEQYIKMN RGINDSKDLP
EEYLSTIYEE IEGKKIAMKE TKEHTIATKS NKQNVASEKQ RRLLYNLEME QMAKTAKALM
EAVSHAKAPF TSATHLDHVR PMFKLVWTPL LAAYSIGLQN CDETEVASLC LEGIRCAIRI
ACIFGMQLER DAYVQALARF SLLTASSSIT EMKQKNIDTI KTLITVAHTD GNYLGNSWHE
ILKCISQLEL AQLIGTGVKT RYLSGSGREK ESSLKGYTSA GEEFMGLGLV GGGVDKRQMA
SIQESVGETS SQSVVVAVDR IFTGSTRLDG NAIVDFVRWL CAVSMDELAS PHHPRMFSLQ
KIVEISYYNM NRIRLQWSRI WQVIGDHFNK VGCNPNEDVA IFAVDSLRQL SMKFLEKGEL
ANFRFQKDFL RPFEHIMKKN RSPTIRDMVI RCITQMVNSQ AANIRSGWKN IFAVFHQAAS
DHDGNIVELA FQTTGHIVTT IFQHHFPAAI DSFQDAVKCL SEFACNASFP DTSMEAIRLI
RYCGKYVSER PRVEYTSDDM NVAPGDRVWV RGWFPILFEL SCIINRCKLD VRTRGLTVMF
EIMKSYGHTF EKHWWQDLFR IVFRIFDNMK LPEQQSEKSE WMTTTCNHAL YAICDVFTQF
YEALNEVLLS DVFAQLHWCV KQDNEQLARS GTNCLENLVI SNGEKFSPEW LMSSSRKVSA
IFKLVFEIHI SSAQTKSIWC HCLYLVMCYI QIQLKFHGLN FCFNYCFILA FNLSSHIDQK
LFASLLIKCV VQLELIQTID NIVFYPATSK KEDAEHMVAA QRDTLDADIH IDTEDQGMYK
YMSSQHLFKL LDCLQESHSF SKAFNSNYEQ RTVLWRAGFK GKSKPNLLKQ ETSSLACCLR
ILFRMYVDEN RKDSWEEIQH RLLTVCSEAL GYFITVNSES HREAWTSLLL LLLTKTLKIS
DEKFKAHASM YYPYLCEIMQ FDLIPELRAV LRKFFLRIGA VLNVLQLGLG GNSD
//