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Database: UniProt
Entry: G3VCX5_SARHA
LinkDB: G3VCX5_SARHA
Original site: G3VCX5_SARHA 
ID   G3VCX5_SARHA            Unreviewed;      1734 AA.
AC   G3VCX5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSSHAP00000001029.2};
GN   Name=ARFGEF2 {ECO:0000313|Ensembl:ENSSHAP00000001029.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000001029.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000001029.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000001029.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR   Ensembl; ENSSHAT00000001043.2; ENSSHAP00000001029.2; ENSSHAG00000010317.2.
DR   GeneTree; ENSGT00940000158950; -.
DR   HOGENOM; CLU_000691_1_2_1; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032629; DCB_dom.
DR   InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR046455; Sec7/BIG1-like_C.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF124; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF20252; BIG2_C; 1.
DR   Pfam; PF16213; DCB; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF09324; Sec7-like_HDS; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          605..794
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          224..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1734 AA;  197019 MW;  3AC6E3B578E60FE9 CRC64;
     MQESQTKSMF VSRALEKILA DKEAKRPQHS QLRRACQVAL GEPLPALPPK ANFIEADKYF
     LPFELACQSK SPRVVSTSLD CLQKLIAYGH ITGNAPDSGA PGKRLIDRIV ETVCNCFQGP
     QTDEGVQLQI IKALLTAVTS PHIEIHEGTI LQTVRTCYNI YLASKNLINQ TTAKATLTQM
     LNVIFTRMEN QALQEARELE KTMHPKPQSP VLQAMAGSPK LNQLKHNQLP SKTSTPEKTG
     LTNGEHQRRG SHEDRIENGE AQLEGGPALS GMFWVVCFLI VLKRNLLFEG KIRYHSKIYF
     MSKIPWNSGK YYLSSSFESD VHGPQVAAKF SHILQKDAFL VFRSLCKLSM KPLGEGPPDP
     KSHELRSKVV SLQLLLSVLQ NAGPVFRTHE MFINAIKQYL CVALSKNGVS SVPDVFELSL
     AIFLTLLSNF KTHLKMQIEV FFKEIFLNIL ETSTSSFEHK WMVIQTLTRI CADAQCVVDI
     YVNYDCDLNA ANIFERLVND LSKIAQGRSG HELGMTPLQE LSLRKKGLEC LVSILKCMVE
     WSKDLYVNPN HQTSLGQERS TDQDLGEPKG LDIRRRSSVS SMDSTMSSGI GSVGTQTSVP
     DDPEQFEVIK QQKEIIEHGI ELFNKKPKRG IQYLQEQGML GTPVEDIAQF LHQEERLDST
     QVGDFLGEST RLNKEVMYAY VDQLDFCGKD FVSALRIFLE GFRLPGEAQK IDRLMEKFAA
     RYLECNQGQT MFASADTAYV LAYSIIMLTT DLHSPQVKNK MTKEQYIKMN RGINDSKDLP
     EEYLSTIYEE IEGKKIAMKE TKEHTIATKS NKQNVASEKQ RRLLYNLEME QMAKTAKALM
     EAVSHAKAPF TSATHLDHVR PMFKLVWTPL LAAYSIGLQN CDETEVASLC LEGIRCAIRI
     ACIFGMQLER DAYVQALARF SLLTASSSIT EMKQKNIDTI KTLITVAHTD GNYLGNSWHE
     ILKCISQLEL AQLIGTGVKT RYLSGSGREK ESSLKGYTSA GEEFMGLGLV GGGVDKRQMA
     SIQESVGETS SQSVVVAVDR IFTGSTRLDG NAIVDFVRWL CAVSMDELAS PHHPRMFSLQ
     KIVEISYYNM NRIRLQWSRI WQVIGDHFNK VGCNPNEDVA IFAVDSLRQL SMKFLEKGEL
     ANFRFQKDFL RPFEHIMKKN RSPTIRDMVI RCITQMVNSQ AANIRSGWKN IFAVFHQAAS
     DHDGNIVELA FQTTGHIVTT IFQHHFPAAI DSFQDAVKCL SEFACNASFP DTSMEAIRLI
     RYCGKYVSER PRVEYTSDDM NVAPGDRVWV RGWFPILFEL SCIINRCKLD VRTRGLTVMF
     EIMKSYGHTF EKHWWQDLFR IVFRIFDNMK LPEQQSEKSE WMTTTCNHAL YAICDVFTQF
     YEALNEVLLS DVFAQLHWCV KQDNEQLARS GTNCLENLVI SNGEKFSPEW LMSSSRKVSA
     IFKLVFEIHI SSAQTKSIWC HCLYLVMCYI QIQLKFHGLN FCFNYCFILA FNLSSHIDQK
     LFASLLIKCV VQLELIQTID NIVFYPATSK KEDAEHMVAA QRDTLDADIH IDTEDQGMYK
     YMSSQHLFKL LDCLQESHSF SKAFNSNYEQ RTVLWRAGFK GKSKPNLLKQ ETSSLACCLR
     ILFRMYVDEN RKDSWEEIQH RLLTVCSEAL GYFITVNSES HREAWTSLLL LLLTKTLKIS
     DEKFKAHASM YYPYLCEIMQ FDLIPELRAV LRKFFLRIGA VLNVLQLGLG GNSD
//
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