ID G3VEY7_SARHA Unreviewed; 1230 AA.
AC G3VEY7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Tudor domain-containing protein 5 {ECO:0000256|ARBA:ARBA00013420};
GN Name=TDRD5 {ECO:0000313|Ensembl:ENSSHAP00000001741.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000001741.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000001741.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000001741.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TDRD5 family.
CC {ECO:0000256|ARBA:ARBA00010384}.
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DR AlphaFoldDB; G3VEY7; -.
DR STRING; 9305.ENSSHAP00000001741; -.
DR Ensembl; ENSSHAT00000001758.2; ENSSHAP00000001741.2; ENSSHAG00000001552.2.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00940000159902; -.
DR HOGENOM; CLU_013593_0_0_1; -.
DR TreeFam; TF342664; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007281; P:germ cell development; IEA:InterPro.
DR CDD; cd09985; LOTUS_1_TDRD5; 1.
DR CDD; cd09975; LOTUS_2_TDRD5; 1.
DR CDD; cd09976; LOTUS_3_TDRD5; 1.
DR CDD; cd20419; Tudor_TDRD5; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 3.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR037982; TDRD5_LOTUS_2.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948:SF80; TUDOR DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF12872; OST-HTH; 3.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51644; HTH_OST; 3.
DR PROSITE; PS50304; TUDOR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 221..294
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 341..416
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 506..580
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 733..792
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 20..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 136013 MW; 62B1B8A687F066EF CRC64;
MCHRCSGSDL ALLSAALRCP CRRPPLPRPP PPPLPLRLRT ALWPRPQEPT VAGPGRGPGV
PRARGWAPIP GTAAAAAARP APRSRPAAPK AAARAAAGAN ARGPGRRGRG RTATPPLPAL
SCGLAAPQLS RGPRRPRAAS RQGPGVPRPG RQDGRAPLRR RKAPPSQLAL LPAAPRAQDS
GQREKPVAAA AVGGERGELS SSGGPVAQLG GVGSMSDQER IQECLRKEIR SLLISTKDGL
TPQQLEREYL SMVGNHLPLR ILGYRSTMEL VLDMPDVVSV CPCGDGTVIL KAIPDETTKG
IASLVAKQRS SNKLRNSTQK GRANVGSSSG SRRRLPYRGR IPPILPAVVK SELKDLLAFS
PILLSDFEKA FAKRFGRSFQ YMQYGFLSMF EVLSAASDII AVEQTRAGSL LTLKRNLPSE
QKRGLPAGKT PQVGTKQPKS SMPTPIVRTY LPEPASATET LKQPHPVKTT ELNGMETSCL
DQSEKLNQLE NTFKSVIAQI GPGGTINSEL KKKIKFVASK FPQGLLISKL LGEFEAVFKE
PLSPKRLGFL NVAELVGSLS DILHVEFREG EQDLLVFDAE MKHLTTDKKI EDQASMSSPP
RNSLSSPDIK DTSWNYSVEK HRDIEEKVCK KFNLITKPVP LHMGMKQSQL NLEMSGYEIP
PDAVQNRKLC SLPPLDSSTL VGVFVEYIIS PSQFYIRIYS RDSSELLEDM MIEMRRCYSN
QLVSDRYIMP ESFIQPGHLC CVRISEDKWW YRVIIHRVLG KQEVEVFYPD FGNLGTVQKS
SLRFLKCCYI KLPAQAIPCS LAWVRPIEEH WTPQAILQFQ KLCGLKPLVG VVDEYVDGVL
NLFLCDTSSN EDIYFHHVLR AEGHAIVCRE NVPSKGFREL NPLALYTKCS PRPEEPGLTE
LGLPSHQHYF NEDREITSPE NELIPLRGAG DRTSISYLEP EAEMLFLGSD IGSPEAQDED
CQESQELEYP IEMPYLESVS IGDDVWDENW LPLQSDREKR NGNAALLFTS GRKQCQPCQE
SLQKEWCSAA EELWNAAWQH SESENDMKIE LKTSEFQEQD AQETITDIAK SHKQLNLEDS
SDSSTLSKSL EDFYISLIHS QQSAELNHSE PGRVQTLPKQ IQLSTAALTC NLLPTVVDSQ
EKHTGLKEIA PENMKNEDFS GNHALTMFKD STCAQGSMEQ ISFILSPEHS VSQKLFIPRS
TATAALGAAA RLAMSSSLLH WYPRLRRMEA
//
