ID G3VF26_SARHA Unreviewed; 1849 AA.
AC G3VF26;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Plexin A1 {ECO:0000313|Ensembl:ENSSHAP00000001780.2};
GN Name=PLXNA1 {ECO:0000313|Ensembl:ENSSHAP00000001780.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000001780.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000001780.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000001780.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9305.ENSSHAP00000001780; -.
DR Ensembl; ENSSHAT00000001799.2; ENSSHAP00000001780.2; ENSSHAG00000001587.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01050000244850; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF35; PLEXIN-A1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1849
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029782965"
FT TRANSMEM 1196..1220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..483
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 480..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1217..1251
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1849 AA; 205621 MW; 2CC397DF9058AAEB CRC64;
MRAAVHPWAL LLLGAVWAMA EPPFRTFPVS DWSLTHLVVH NKTGEVYVGA VNRIYKLSSN
LTLLRTHVTG PVDDNEKCYP PPSVQSCPHG LVTTNNVNKL LLLDYAANRL LACGSASQGI
CQFLRLDDLF KLGEPHHRKE HYLSSVNESG TMSGVLIEVP GGHDKLFIGT PIDGKSEYFP
TLSSRKLMEN EENAEMFGFV YQDEFVSSQL KIPSDTLSKF PAFDIYYIYS FSSEQFVYYL
TLQLDTQLTS PDSTGEQFFT SKIVRLCVDD PKFYSYVEFP IGCVQGGVEY RLVQDAYLSK
PGRALARQLG VSQADDVLFT VFAQGQKNRV KPPKESVLCL FTLKKIKDKI KERIQSCYRG
EGKLSLPWLL NKELGCINSP LQIDDDFCGQ DFNQPLGGTV TIEGTPLFVD KEDGMTSVAA
YDYQGHTVVF AGTRSGRIKK VIDLMYENVV AHEGSSILRD LVLSPSRQYI YAMTEKQVGA
EPAGTSGRGR GVPSGRRGRG EPSGPWCRQT GCSRKDRCER ADEPQRFASD LLQCVQLTVR
PKNISVTVSE LVLQAWNVPD LSAGVNCSFE DFTESESRIE DGKIHCRSPS AKDVVPITRG
QGDKRVVKLY LKSKETGKKF ASVDFVFYNC SVHQSCLSCV NGSFPCHWCK YRHICTHNAA
DCSFQEGRVN VSEDCPQILP STQIYVPVGV VKPITLTAKN LPQPQSGQRN YECIFHIPGS
PARVTALRFN STSIQCQNTS YTYEGNDISD LPVNLSVVWN GNFVIDNPQN IQAHLYKCSA
LRESCGLCLK ADPRFECGWC VAEKRCSLRH HCPAPDVGWM HASSGNSRCA DPKILKVGRA
SGGRDCGPPG GREAGAAGSA LSMAWGRAGV LPLPPPPSTA PSLGLGGLSL QSTQQAPLTS
VLFLQTPTFY RVTPARGPLS GGTWIGIEGN HLNAGSDVAV SIGGRPCTFS WYVRERAWEN
SREIRCRTPP GQNPGGASIV ININRAELSN SDVKYNYTED PTIQKIDPEW SINSGGTLLT
VTGTNLATIR EPRIRAKYGS AEREDTCVVY NDTTMVCQAP SIDNPTRSPP ELGDRPDELG
FVMDNVRSLL IINSTNFLYY PDPVFEPLSP SGILELKPSS PLILKGRNLL PPASGNSRLN
YTVLIGSTPC VLTVSETQLL CESPNLTGQH KVTVCAGGFE FSPGTLQVYS DSLLTLPAII
GIGGGGGLLL LVIIVVLIAY KRKSRDADRT LKRLQLQMDN LESRVALECK EAFAELQTDI
HELTNDLDGA GIPFLDYRTY AMRVLFPGIE DHPVLKEMEV QANVEKSLTL FGQLLNKKHF
LLTFIRTLEA QRSFSMRDRG NVASLIMTAL QGEMEYATGV LKQLLSDLIE KNLESKNHPK
LLLRRTESVA EKMLTNWFTF LLYKFLKECA GEPLFMLYCA IKQQMEKGPI DAITGEARYS
LSEDKLIRQQ IDYKMLTLNC VNPENENAPE IPVKVLNCDT ITQVKEKLLD AVYKGVPYSQ
RPKAGDMDLE WRQGRMARII LQDEDVTTKI DNDWKRLNTL AHYQVTDGSS VALVPKQNSA
YNISNSSTFT KSLSRYESML RTASSPDSLR SRTPMITPDL ESGTKLWHLV KNHDHLDQRE
GDRGSKMVSE IYLTRLLATK GTLQKFVDDL FETIFSTAHR GSALPLAIKY MFDFLDEQAD
KHQIHDYDVR HTWKSNCLPL RFWVNVIKNP QFVFDIHKNS ITDACLSVVA QTFMDSCSTS
EHKLGKDSPS NKLLYAKDIP NYKSWVERYY SDIAKMPAIS DQDMSAYLAE QSRLHLSQFN
SMSALHEIYS YITKYKDEVG VPAPGQLPGP AERIHTPGFG PFPCSFCLF
//
