ID G3VGI3_SARHA Unreviewed; 1835 AA.
AC G3VGI3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dedicator of cytokinesis 5 {ECO:0000313|Ensembl:ENSSHAP00000002287.2};
GN Name=DOCK5 {ECO:0000313|Ensembl:ENSSHAP00000002287.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002287.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002287.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002287.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9305.ENSSHAP00000002287; -.
DR Ensembl; ENSSHAT00000002311.2; ENSSHAP00000002287.2; ENSSHAG00000002033.2.
DR eggNOG; KOG1998; Eukaryota.
DR GeneTree; ENSGT00940000157734; -.
DR HOGENOM; CLU_000595_2_1_1; -.
DR InParanoid; G3VGI3; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046849; P:bone remodeling; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR CDD; cd11708; DHR2_DOCK5; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR030717; DHR2_DOCK5.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 404..590
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1193..1604
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1642..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1760..1775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1823
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1835 AA; 211390 MW; F34B2650B821B7B6 CRC64;
MYEGWFRGYT LRNKAKKGIF PETYIHLKEA TVEDRGQHET VIPSEVPLVH ELTSTLREWA
VIWHKLYVNN KVTLFRQLQQ MTYSLIEWRS QILSGTLPKD ELAELKKKVT AKIDHGNRML
GLDLVVRDEN GNILDPDETS TIALFRAHEV ASQRIEERIQ EEKSILQNLD LRGQSIFNTM
HTYCLYVNFK NFVCNIGEDA ELLMALYDPD QSRFISENYL IRWGSNGMPK EIEKLNNLQA
VFTDLSSTDL IRPKISLVCQ IVRVGHMELK EGKKHTCGLR RPFGVAVMDI TDIIHGKVDD
EEKQHFIPFQ QIAMETYIRQ RQLIMSPLIT SHVIGENEPL TSVLNKVIAA KEVNHKGQGL
WVSLKLLPGD LTQVQKDFSH LVDRSTAIAR KMGFPEIILP GDVRNDIYVT LIHGEFDKGK
KKTPKNVEVT VSVYDEDGTL LEKAIHPGAG YEGISEYKSV VYYQVKQPCW YETVKVSIAI
EEVTRCHLRF TFRHRSSQES RDKSERAFGV AFVKLMNPDG TTLQDGRHNL VVYKGDNKKM
EDAKSYLTLP STKIEMEDKD FSPGKNTHLS TFTATKDSTK DSFQIATLIC STKLTQNVDL
LGLLNWRSNS QNIKHNLKKL MEVDGGEIVK FLQDTLDALF NIMMEMSDNE TYDFLVFDAL
VFIISLIGDI KFQHFNPVLE TYIYKHFSAT LAYVKLTKVL NHYVGNAEDS SKTDLLFAAL
KALKYLFRFI VQSRVLYLRF YGQSEDGDEF NNAIRHLFLS FNNLMDRPLE EAVKIKGAAL
KYLPNIINDV KMVFDPVELS VLFSKFIQSI PDNQLVRQKL NCMTKIVESH LFHQTECRDA
LLPLLIDQLS GQLDDNCNKP DLEASSQLLR NILEVLDRKD VGPTSMHIQL IMERLLRRIN
RTVIGMSRQS PHIGSFVACM TAILRQMDDF HYNYYISTFK TRQDIIDFLM ETFIMFKDLI
GKNVYPPDWM VMNMMQNRVF LRSINLFAEV LTKFFMDQAS FELQLWNNYF HLAVAFLTHE
SLQLETFSQA KRSKMIKKYG DMRKEIGFRI RDMWYNLGPH KIKFIPSMVG PILEVTLTPE
TELRKATIPI FFDMMQCEFN FSGNHNFQMF ENELITKLDQ EVEGGRGDEQ YKVLLEKLLL
EHCRKHKYLA SSGEVFALLV SSLLENLLDY RTIMHDESKE NRMSCTVNVL NFYKEKKRED
IYIRYLYKLR DLHRDCENYT EAANTLLLHA ELLQWSDKPC VPHLLQRDSY HVYSQQELKE
KLYQEIISYF DKGKMWEKAI KLSKELAETY ESKVFDYEGL GNLLKKRASF YENIMKAMRP
QPEYFAVGYY GQGFPSFLRN KIFIYRGKEY ERREDFNLKL LTQFPNAEKM TSTTPPGEEI
KSSPKQHMQC FTVKPVMNLP PNYKDKPVPE QILNYYRANE VQQFQHSRPF RKGEKDPDNE
FATMWIERTT YTTAYTFPGI LKWFEVKQVT TEEISPLENA IETMELTNEK ISNSVQQHAW
DRSLSVHPLS MLLNGIVDPA VMGGYSNYEK AFFTEKYQQE HPEDQEKIEL LKRLIALQMP
LLGEGIRIHG EKLTEQLKPL HDRLTTCFQE LREKVEKLYG VITLPPTLTE RKQSRTGSVV
LPYIMSSTLR RLSVTSVASS VISTSSTSSD STPSRPGSDG SILEPLLERR ASSGAKVEDL
SLREDGDNRI GKFKRKDWNI SKSQVIAERE PEADLLSPTS KVQRPKSLQL VDSRLTLFHG
SSLPSAVPLS PPPLTPKTPR TQSSPTLQVD GLMSSGSKTL PPPPPPKSKP YESSSQRNST
EVAPPLPIRR EAKAPPPPPP KARKSGVLSM EPGSQ
//
