ID G3VI10_SARHA Unreviewed; 637 AA.
AC G3VI10;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=LOC100913276 {ECO:0000313|Ensembl:ENSSHAP00000002814.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002814.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002814.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002814.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|RuleBase:RU361242}.
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DR AlphaFoldDB; G3VI10; -.
DR STRING; 9305.ENSSHAP00000002814; -.
DR Ensembl; ENSSHAT00000002846.2; ENSSHAP00000002814.2; ENSSHAG00000002491.2.
DR eggNOG; KOG3736; Eukaryota.
DR GeneTree; ENSGT00940000160161; -.
DR HOGENOM; CLU_013477_4_1_1; -.
DR InParanoid; G3VI10; -.
DR TreeFam; TF352661; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF50; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|RuleBase:RU361242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|RuleBase:RU361242};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361242}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361242"
FT DOMAIN 179..307
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
FT DOMAIN 492..617
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|Pfam:PF00652"
SQ SEQUENCE 637 AA; 73522 MW; ADE25077402D8FED CRC64;
MALRGRFPRV FFIRVVLVFV LHIALLFFIK RISHILKMGI SEPLKNPLLA SSWDITKKED
FEDLDESMKE VIRFIKMKQA YVSKNLKDEE KNSPRTWKFK DGNKAKDKSQ RKVFPNSALF
NHWGNDLTEN QQIEAQSLFL EFGYNVYLSN QLPLNRSIPD TRSPRCLKKE YPAQLPTVSV
ILTIMNDAIS TIQRAITSII YRTPPHLLKQ LILVDDFSPN EELKEYLEKQ IQIYDLKYPR
LLTLIRHNKR EGIATAWFSG WQAATADVVI LLDAHIEVNI GWAEPILSRI QEDQTVVLSP
MLDKIHFDTL NVKENALAAL GFDWALWNHY DPLPKDWYNL EDDSAPVKSP SIMGNFAADR
LFLGEIGSLD MGMKAYEGES VELGVRVWQC GGKIEVLPCS RVAHLEQAHK PYVPNVRSAM
KRNALRIAEI WMDEYKPMVY YSWNLPMKNH GIDYGDVSSR KKLRKKLKCK SFDWYLRNVY
PDLKPFQNIS AYGTMKNSLN EKFCLDHGPI TADAPIMSIC NGNHTQTVLY FLSGELHVGM
LNPNFRLGDH CLIDSNQGQE LTFKPCFQAA ANGWHMYWDF KQGRAITNRT TRRCLEIKED
GSGSYALILQ KCTGQRWKIQ HIVKTLESLW KSRIALI
//
