ID G3VII7_SARHA Unreviewed; 3191 AA.
AC G3VII7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=FRAS1 related extracellular matrix 2 {ECO:0000313|Ensembl:ENSSHAP00000002991.2};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSSHAP00000002991.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002991.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002991.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002991.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_003764588.1; XM_003764540.1.
DR STRING; 9305.ENSSHAP00000002991; -.
DR Ensembl; ENSSHAT00000003025.2; ENSSHAP00000002991.2; ENSSHAG00000002649.2.
DR GeneID; 100925428; -.
DR KEGG; shr:100925428; -.
DR CTD; 341640; -.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG2090; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000155313; -.
DR HOGENOM; CLU_000394_0_0_1; -.
DR InParanoid; G3VII7; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3134..3158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 328..422
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 447..550
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 573..695
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 720..827
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 848..939
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 965..1057
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1086..1188
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1209..1302
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1323..1419
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1440..1532
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1552..1641
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1675..1772
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1779..1878
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1891..2002
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2017..2123
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2134..2240
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2258..2362
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 3162..3191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3191 AA; 354315 MW; 20897413F63400E9 CRC64;
MHHAVSGASR TFGVVPAQPA TARSVTSRAP WAQLPPWLFL LILSLARCVS AHLESSSSAR
VSLGFPGPSG TPAEEAIVLA NRGLRVPFGR AVWLDPLHDL VLQVQPGDRC QVGVLDNDAL
AQLPGHLSPK RFPCDFGPGE VSYSHLGARS PSKDRVRLQL RYDTPSGSVV LPLVLEVEVL
FTQLEIVTRN LPLVVEELLG TSNPLDRRSL EFTYQPETEE CRVGILSGLG ALPRYGKLLH
YPQALRAERE GGGERGLRKP LMMDCSAFLE LGVRYLHIAP GRSPNRDWVP MVVELHPKDA
PIGSPSLKRE HFQVLVRIRG GIENTPPKPS FVAMMMMEVD QFVLTALTPD MLAAEDSESD
PDLLVFNLTS PFQQGQGYLV STDDRSLPLS SFTQRDLRLL KIAYQPPAED SDQERLFELE
LEVVDPEGAA SDPFAFMVVV KPMNTLAPVV TRNTGLILYE GQSRPLTGPP GSGSSNLVIS
DEDDLDAVQL EVVAGLQHGH LALLGSPGGD PGARPPGKYF TVAELEAGQV VYQHDDNDGS
LSDNLVLRMV DGGGRHQVQF LFPITLVPVD DQPPVLNANT GLVLAEGDTV PIPPLALSAT
DIDSDDSMIL FVLEPPYSAT GQFLLRQTQP PRDGEELSGG PWRQVVDSQK GILYERSVIE
WRQQDIVEGR LFYRHIGPHS PGLGPVIDQF IFRVQDDHDP PNQSGLQKFV LRIHPVDRLP
PEVGSGCPLR MVVQEYQLTP LRKKWLRYTD LDTDDRELRY TVTQPPTDTD ENHAPAPLGT
LVLTDNPSVT VTHFTQAQIN HHKIAYRPPE QELGVAARVA QFQYRVEDQS GNMVPGTFTF
YLQPVNNQPP EILNTGFTIQ ERGQHILSET ELHATDVDTV ATQISFTLTQ APKHGQMQLN
QRKLGVGEFF HLEDIVQGRV TYVHNGDEYP SDSCSIEVSD GLHVVPITLR ANVRPIDDEV
PILSLPTGTL GSYLDVLENE AAEITAHVIK GTDEDTDDLM LTFLLENPPL YGEILVNGVP
AEQFSQREIL EGSVVYAHTS GEIGPFPKED SFNLTLSDMS QEWRIGSNIV RGVTVLVTIL
PIDNQAPEVT VGEQFMVVEG DKRVITTSHI SAEDIDSPND DILCTIVTQP ASGYVENISP
APGSEKSRAG IAISAFTLKD LKQGHIYYVQ SIHKGVEPVE DRFAFRCSDG INFSHRHFFP
IVIIPTNDEE PEMFMREFMV MEGMSLVIDT PILNAADGDI PADDLTFVIT RFPSHGHIMN
QLINGTVLVE SFTLDQIIES SSIIYEHDDS ETQEDSFDIK LTDSKYSVEK RVIILVIPVD
DETPRMTINN GLEIEMGETK IINNKVLMAT DLDSEDKSLV YIIRYGPGHG LLQRQRPDGA
VENITLGMNF TQDEVDRNLI QYVHLGQEGI RDLIKFDVTD GINPLIDRYF YVSIGSIDMV
FPDVISKGVS LKEGGRVTLT TDLLSTSDIN SPDENLVFSI TRAPMRGHLE CTDHSGVPIT
SFTQLQLAGN KIYYIHTSDD EVKMDSFEFE VTDGHNSVFR TFRISISDVD NKKPVVTIQN
LVVSESENKL ITPFELTVED RDTPDHLLKF TVIQMPVHGH LMFNNTRPVM VFTKQDLNEN
LISYKHDGTE STEDSFSFTV TDGTHADFYV FPDTVFETRR PQRMKIQVIA VDNSSPQIVV
NKGASTLRIL TTGHLGFMIT NKILKVEDKD SLHISLKFIV TEAPQHGFLF NLGKGNHSIT
QFTQADIDDM KICYVLREGA NATSDSFHFT VEDGGGNKLT NQHFHLNWAW ISLEKEYYLV
NEDFKFLDIV LKRRGYLGET SFVSIGTQDG TAKKDRDFKG KAQKQVQFNP GQTTATWRVR
ILSDGEHEQS ETFQVVLSEP VMAALEFPAV TTVEIIDPGD ESTVFIPQSV YTIEEDVGEL
FIPIKRSGDV SQELMVICYT RQGTATGTVP TSVLSYSDYI SRPEDHTSIV RFDKDEQEKM
CRIVIIDDSL YEEAETFHVL LSMPMGGRIG SEFPGAQVTI IPDKDDEPTF YFGAVEYSVD
ESAGFVEVCI WRTGTDLSRL SSVMVRSRKS EPSSADAGTD YVGISRNLDF APGVNMQTLR
VIILDDRGQP ILEGIERFEL VLRMPMNAAL GEPNKATIFI NDSVSDLPKM QFKERVYSGN
ENDGQIVAMI YRSGDIQHKS SVRCYTRQGS AQVMMDFEER PNTDSSIITF FPGETEKPCI
LVLMDDVIYE EEEELRLVLG TPQSESPFGA SVGEQNETLI KIRDDADKTI IKLGETKFSV
HEPKGPSQSV IVKIPVLRQG DTSKVSIVRV HTKDGSAVSG EDYHPVSEEI EFKEGETQHI
VEIEVLFDGV REMREAFTVH LKPDENMVAE TQVTKAIVYI EEMNSMADVT FPSVPQVVSL
LIYDDTFQIK DSPGPVPGYP VACVTACNPK YSDYEKTGSI CASESINDTL TRYRWLVSAP
TGPDGVTSPM KEVDFDTFFT SSKMITLDSI YFQAGSRVQC AARAVNADGN EGLELMSPIV
TVNREEGLCQ PRVPGVVGAE PFSAKLRYTG SEDTDYTNLI KLTVTMPHID GMLPVISTRE
LSNFELTLSP DGTRVGNHKC SNLLDYTEVK THHGFLTDAT RNSEVIGETY PYQYSASIRG
SGTLRFYRNL NLEACLWEFV SYYDMSELLT DCGGSIGTDG QVLNLVQSYV TLRVPLYVSY
VFHSPVGVGG WQHFDLKSEL RLTFVYDTAI LWNDGIGSPP EAELQGSLYP TSMRISEEGR
LVVNFKTEAR FHGLFVLSHP ASSTSSMIIS ADHPGLTFSL RLIRSEPTYN QPVQQWSFVS
DFSVRDYSGT YTVKLIPCTT SPHQEYRLPV ICNPREPITF DLDIRFQQVS DPVAAEFSLN
TQMFLLSKKS LWLSDGSMGF GQESDVAFTE GDIIYGRVMV DPVQNLGDSF YCSIEKVFLC
TGADGYVPKY SPSNAEYGCL ADSPSLLYRF KIVDKAQPET QATSFGNVLF NAKLAADDPE
AVLLVKQPGS DGFKVDSTPL FQVSLGREWY IHTIYTVRSK DNTNRGIGKR SVEYQYHSLS
NPGILKTSTE NRKKREAKNA PSLAKEIGAE NNRGTNIQHI ALDRSNKKQI PQREVPLDGV
LPRELNNSNP EVNLITVITG VATGLLTICL IAITVLLLKR KQSSKKDAPE GSGSSEPMMP
QHRYTSDSSE V
//
