ID G3VKT1_SARHA Unreviewed; 526 AA.
AC G3VKT1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Transmembrane and coiled-coil domains 4 {ECO:0000313|Ensembl:ENSSHAP00000003786.2};
GN Name=TMCO4 {ECO:0000313|Ensembl:ENSSHAP00000003786.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000003786.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000003786.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000003786.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3VKT1; -.
DR Ensembl; ENSSHAT00000003823.2; ENSSHAP00000003786.2; ENSSHAG00000003332.2.
DR GeneTree; ENSGT00390000001400; -.
DR HOGENOM; CLU_016865_0_0_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 154..188
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 526 AA; 57113 MW; 444CAA73E573C4C4 CRC64;
MAGSRMATPE GQGQEAGAYP EPAIEAQPHL PTGKELGEAS RFAYTALCGM SLAWLFPDPE
QSSFRTEFVE SLVKWLELSE TVLPSMVAFA NGLGGEEEAT FAEILLKDPV LKNDPMVIIQ
DLLAFSLRNG CYDARARVLV CHVTWLLKIP PEELENLEEM FLESLKERQE EESEAAETSR
KKRENRKKWK RYLLIGLATV GGGTAIGLTG GLAAPFMAAG AAAIIGTTGA AALGSVAGIA
VITSLFGAAG AGLTGYKMKK RVGAIEEFEF LPLTDGKQLH ITIAITGWLC SGKYGMFTTP
WATMARSSEQ YCLAWESKYL MELGSALETL LNGLVNMMAQ EALKYTILSG ILTALTWPTS
LLAVANVIDN PWGVCLRRSA EVGKHLAHVL LSRQQGRRPV TLIGFSLGAR VIYFCLQEMA
QEKDCQGIIE DVVLLGAPVE GEAKYWKPFT KVVSGKIING YSRGDWLLSF VYRTSSVQLK
VAGLQPVNLD DRRMVNMDLS SVAVGSGSLC PELVPPWKAF IEIGDC
//
