ID G3VMC4_SARHA Unreviewed; 1198 AA.
AC G3VMC4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Partner and localiser of BRCA2 WD40 domain-containing protein {ECO:0000259|Pfam:PF16756};
GN Name=PALB2 {ECO:0000313|Ensembl:ENSSHAP00000004329.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004329.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004329.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004329.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3VMC4; -.
DR Ensembl; ENSSHAT00000004373.2; ENSSHAP00000004329.2; ENSSHAG00000003810.2.
DR GeneTree; ENSGT00390000014423; -.
DR HOGENOM; CLU_008217_0_0_1; -.
DR InParanoid; G3VMC4; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR042417; PALB2.
DR InterPro; IPR031920; PALB2_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14662; PARTNER AND LOCALIZER OF BRCA2; 1.
DR PANTHER; PTHR14662:SF2; PARTNER AND LOCALIZER OF BRCA2; 1.
DR Pfam; PF16756; PALB2_WD40; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 847..1196
FT /note="Partner and localiser of BRCA2 WD40"
FT /evidence="ECO:0000259|Pfam:PF16756"
FT REGION 39..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 133904 MW; A246C041AC84EE45 CRC64;
MEDSVAKVLS CEEKEKLKEK LAFLKREYSK TLARLQRAQR AEKAKNSSKI EQSCMLKQET
SKQANSEPED KFSPDDKLET DTLQIDACLD AEIKEKTAVT LDFESELLST GNDSSGVCPE
HVGDNCQKNF FNNITEPDNE KKQNKQPLNR MKNRKKILVS KGSESFFVSN SLINSGQRQQ
KQRFAIENPE LPVFHIRNQF SCGENEMQNS PRSTTEISEC LVAPATELEN DASGILKDLP
RIAALSLHNP LDDSNIQQLG CVSSEKICDN YKLATQCSMN LTHISPKKLE EGRQEYVISP
GDQMVNDDIN VDKMSNILIL PSDDKSFSAD ELNYSLCKNT HIDEQNHSLK PFESFSNLLN
NRDENLQKKE VLSENVSPSI EMISPGPSEN PLNSCTVFDG LPFPVEYYVR TTRQMSNCQR
TINLEAVIQN QLGVKRKGFK HKRKPVMKNL DLSSQEQSEF PLSDQGSSSS PLQKSFSSTP
EGSPSALPNK DNDFALNTCK RRSSRRQRGK RFFYKKVDDP DSELQVADKL SIKTPKKDVA
LCKEIPKKKE HAQDQKKVTG KSRCTLVNVD RKAPTSTTKG KLDYIQNKNL HSSIGNDSLI
LDDTSFDLSF HLKNEILSFE KLSAGSNSIT DFDLPDEEFG FLKLEKLKSY SAKEVEPFES
GDGKKCNEEN CISLEPLVPK KQVTEKENLA NDITVTRNSH PKKPKSIPPN MLLFTPSSTN
LPATNNQLEA DMCSPVFPIL GPTPVFGSQV HSGSMATEIT APTFCTSKHI YLKEPDSLTG
DNQCNNSPNT LKLDANIHAL DREIKKQPDQ IVSCEKKFDS DCGSQETLPS VDSITFKERL
LLGSTFQTKV RGDPVEIWHD TLELGNLQLV SKLKNPSNSC SVDVSTVWWE VTGCKESCII
TACEFTVSLW KFLDNWQWRK VHTWHFTEIP VLQIIPLWDA CNLVCVALGH LEIREIRLLF
SSAEDECLKQ SLVKSGNIKA VLGLRHKRLV CSNGTLHDHQ VDLMTFSGSG RSKEKQTLMS
PEETILAFAE VQGMQDALLG TTLMSNIVIW NLKTGQLLKK MQIGNAYQAS ICHKAYSDMG
LLFVVLSHPH GKEIESMGNP IFRLIVINPK TALSVDVRPY SLPQGHTGRF LDGDVKDNLA
AAVLTSGTIA VWDLFLGHCR ALLLPNSDGN WSFVKWSGTD SCLLAGQKNG SVFVYSSM
//
