ID   G3VMK8_SARHA            Unreviewed;       500 AA.
AC   G3VMK8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Cyclin-A1 {ECO:0000256|ARBA:ARBA00040596};
GN   Name=CCNA1 {ECO:0000313|Ensembl:ENSSHAP00000004413.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004413.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000004413.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000004413.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006955}.
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DR   AlphaFoldDB; G3VMK8; -.
DR   STRING; 9305.ENSSHAP00000004413; -.
DR   Ensembl; ENSSHAT00000004459.2; ENSSHAP00000004413.2; ENSSHAG00000003884.2.
DR   eggNOG; KOG0654; Eukaryota.
DR   GeneTree; ENSGT00940000157940; -.
DR   HOGENOM; CLU_020695_3_1_1; -.
DR   TreeFam; TF101002; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   CDD; cd20560; CYCLIN_CCNA1_rpt1; 1.
DR   CDD; cd20563; CYCLIN_CCNA1_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR032447; Cyclin-A_N.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR048258; Cyclins_cyclin-box.
DR   PANTHER; PTHR10177:SF254; CYCLIN-A1; 1.
DR   PANTHER; PTHR10177; CYCLINS; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   Pfam; PF16500; Cyclin_N2; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN          298..382
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
FT   DOMAIN          391..500
FT                   /note="Cyclin C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01332"
FT   DOMAIN          395..477
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
SQ   SEQUENCE   500 AA;  56398 MW;  5FD9AE5ACF080D02 CRC64;
     MCLVHISESL PAPIEDCKRH TGVLYSKTLF RTLNAPSPYF STRFTGGRKA FLWLAKDTCA
     FVQGGREGNG ESGLSGLTIS PCSQWPGETE AMRRSISKGR IPLGPAARSQ EICQVVARTQ
     PVQDPPQRTV LGLLTENGQY RRTCGQGITT IRCFSGSENV FPPAGKKLIS NCMVHVPAKQ
     GFDIYVDEPE HGETCSCSCT VREEIAYEDV YEVDTSTLKS DLHFLLDFST VSPMLVDTSL
     QSQFEDHLDI GTDVINVTEY AEEIHQYLRE AEMKYRPKAH YMRKQPDITE GMRTILVDWL
     VEVGEEYKLR AETLYLAVNF LDRFLSCMSV LRGKLQLVGT AAILLASKYE EIYPPEVDEF
     VYITDDTYTK RQLLRMEHLL LKVLAFDLTV PTTNQFLLQY LQKQGVCLRT ENLAKYVAEL
     SLLEADPFLK YVPSLIAAAA YCLANYTVNR HFWPETLAAF TGYSLSEIVP CLSELHRACL
     DIPHRPQQAI REKYKASKCG
//