ID G3VPR6_SARHA Unreviewed; 732 AA.
AC G3VPR6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=LSS {ECO:0000313|Ensembl:ENSSHAP00000005171.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005171.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005171.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005171.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR AlphaFoldDB; G3VPR6; -.
DR STRING; 9305.ENSSHAP00000005171; -.
DR Ensembl; ENSSHAT00000005223.2; ENSSHAP00000005171.2; ENSSHAG00000004524.2.
DR eggNOG; KOG0497; Eukaryota.
DR GeneTree; ENSGT00390000011570; -.
DR HOGENOM; CLU_009074_2_1_1; -.
DR InParanoid; G3VPR6; -.
DR TreeFam; TF300406; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0000250; F:lanosterol synthase activity; IEA:Ensembl.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 81..323
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 381..718
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 732 AA; 83345 MW; 4160A816A5C7BCDD CRC64;
MTEGTCLRRR GGPYKTPPAT ELSRWRLANE EGRQRWTYGP GTDAQRALEA HAVGLDTTKF
FPELPPARSA REGAWKGMKF YSQLQAEDGH WPGDYGGPLF LLPGLLITCR VANISLPAGY
REEMERYLRS VQLPDGGWGL HVEDKSTVFG TALNYVSLRL LGVGPDDPAL VQARTNLHEK
GGALGIPSWG KFWLAILNVY SWEGLNTLFP EMWLFPTWAP AHPSTLWCHC RQVYLPMSYC
YAMRVQGPED ELVRSLRQEL YIEDYSSIDW PAHRNHVAAC DLYTPHSWLL HLVYAVLNLY
ERYHLPSLRK LAVAEVYDHI TADDRFTKCL SIGPISKTIN MLVRWYVDGP ASPAFQEHVS
RIPDYMWLGL DGMKMQGTNG SQLWDTAFAI QAFLEAGAHH MPEFSSCLRD AHEFLRITQI
PDNPENYQKY YRQMNKGGFP FSTRDCGWIV ADCTAEGLKC LLLLQKKCPF LREPVPKERL
YDAVNVLLSM RNSDSGFATY EKKRGGRLLE LLNPSEVFGD IMIDYSYVEC TSAVMQSLKH
FQDCYPEYRA EDIRLTLREG LRYCRQVQRD DGSWEGSWGV CFTYGAWFGL EAFACMGHTY
NASGEAPPEV VKACEFLLSK QMEDGGWGEN FESCEQRRYV QSDQSQLFNT CWALLGLMAA
RHPDTEAIER GVRCVLGKQE PNGDWPQENI AGVFNKSCAI SYTSYRNVFP IWTLGRFSRL
YPQSPLAGKV VM
//
