ID G3VQR1_SARHA Unreviewed; 472 AA.
AC G3VQR1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=GPI-anchor transamidase {ECO:0000256|ARBA:ARBA00019393};
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class K protein {ECO:0000256|ARBA:ARBA00029842};
GN Name=PIGK {ECO:0000313|Ensembl:ENSSHAP00000005516.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005516.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005516.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005516.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBUNIT: Forms a complex with PIGT, PIGS, PIGU and GAA1.
CC {ECO:0000256|ARBA:ARBA00011178}.
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3VQR1; -.
DR STRING; 9305.ENSSHAP00000005516; -.
DR Ensembl; ENSSHAT00000005570.2; ENSSHAP00000005516.2; ENSSHAG00000031205.1.
DR eggNOG; KOG1349; Eukaryota.
DR GeneTree; ENSGT00940000156273; -.
DR HOGENOM; CLU_044656_0_0_1; -.
DR InParanoid; G3VQR1; -.
DR TreeFam; TF300848; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:Ensembl.
DR GO; GO:0003923; F:GPI-anchor transamidase activity; IEA:Ensembl.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR028361; GPI_transamidase.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR48067; GPI-ANCHOR TRANSAMIDASE; 1.
DR PANTHER; PTHR48067:SF1; GPI-ANCHOR TRANSAMIDASE; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500138; GPI8; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 250
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 292
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 472 AA; 52472 MW; B93AFC94DA688841 CRC64;
MSEGRVDAPS SQLPELGPPC GWDPGQQRGA RTRGSGVRGR AVPQGRGRVG EAGKGWAWAG
PSPTAALHPG FGSPAPALGV LVPDAASSGP GCREPACPAG PAPFPRASSL FLMLLPPGPS
LLAPLNFTGT SCRGHLRPQP FWFNYRHVAN TLSVYRSVKR LGIPDSHIVL MLADDMACNP
RNPKPATVFS HKNMELNVYG DDVEVDYRSY EVTVENFLRV LTGRVPPSTP RSKRLLSDDR
SNILIYMTGH GGNGFLKFQD SEEITNVELA DAFEQMWQKR RYHEMLFIID TCQGASMYER
FYSPNVMALA SSQVGEDSLS HQPDLAIGVH LMDRYTFYVL EFLEEIHPAS QANMNDLFQV
CPKSLCVSTP GHRTDLFQRN PQNVLITDFF GSVRKVEITT ERVALNHLKC QKDEELTEPL
NYAEQLPVAQ IIHQKPKQKE WHPPGGFILG LWALILMVFF KTYGIKHMKY VF
//