ID G3VRD0_SARHA Unreviewed; 620 AA.
AC G3VRD0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Exonuclease 3'-5' domain containing 2 {ECO:0000313|Ensembl:ENSSHAP00000005735.2};
GN Name=EXD2 {ECO:0000313|Ensembl:ENSSHAP00000005735.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005735.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000005735.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000005735.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003756424.1; XM_003756376.2.
DR AlphaFoldDB; G3VRD0; -.
DR STRING; 9305.ENSSHAP00000005735; -.
DR Ensembl; ENSSHAT00000005789.2; ENSSHAP00000005735.2; ENSSHAG00000005008.2.
DR GeneID; 100925474; -.
DR KEGG; shr:100925474; -.
DR CTD; 55218; -.
DR eggNOG; KOG4373; Eukaryota.
DR GeneTree; ENSGT00390000014318; -.
DR HOGENOM; CLU_019718_0_0_1; -.
DR InParanoid; G3VRD0; -.
DR TreeFam; TF324246; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0030145; F:manganese ion binding; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008310; F:single-stranded DNA 3'-5' DNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000729; P:DNA double-strand break processing; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF104; EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..261
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 293..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 70271 MW; B3F7DD93903D5949 CRC64;
MLKHNIVATT VATLLGTAVG GLIIWKFFQR WRGKISCTRE HLEEIDGQEL APVKTEPLLS
LLVVPNVSRV ERMLGEKVVT VSETEEWEEV ESLLRRELEQ CPVLGIDCEW VNIEGKACPI
SLLQMASPTG RCILLRLPKL ISGKAALPQT LLDILEDSKI LKVGVGCRED ASKLLQDYHL
TVRGCLDLRN LAMKQRRDLL QNGLSLKSLA ETILNFPLNK SLLLRCSNWD AEELTEEQVA
YAARDAQISV ALFLHLLGCP LSMNSTKNRD VETSWEKVLM KCKDLVDRPF HGKGNNSIMG
EESIGETESP KKTRNLKSRA GGMSSGNQQG RDPRKQKQKS LGKGYSARKS PLYDNCFLHA
PDGQPLCTCD RRKAQWYLDK GIGELVSEDP FVVKLRFEPS GRPESPKDYY LMVKENLCVV
CGKKESYIRK NVVPHEYRRH FPIQMKDHNS HDVLLLCTSC HAISNYYDNN FKQQLAGECG
APIGSEEGLR LLEDPVRRQV RSGARALLNA ENLPAYRKEE LLQGIKEFFN TETVTDLMLQ
EAASLETRIA NESYVPHGLK VVQYHAKGGL RSLMHLESRW RQHFLDSMKP KHLPQQWSVN
HNHRNLLRKH GDNLLMELTS
//
