ID G3VSX8_SARHA Unreviewed; 940 AA.
AC G3VSX8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Espin like {ECO:0000313|Ensembl:ENSSHAP00000006283.2};
GN Name=ESPNL {ECO:0000313|Ensembl:ENSSHAP00000006283.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006283.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006283.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006283.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR AlphaFoldDB; G3VSX8; -.
DR Ensembl; ENSSHAT00000006337.2; ENSSHAP00000006283.2; ENSSHAG00000005471.2.
DR GeneTree; ENSGT00940000156970; -.
DR HOGENOM; CLU_822679_0_0_1; -.
DR InParanoid; G3VSX8; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF0; ESPIN-LIKE PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 10.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 170..192
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 238..265
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 270..302
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 429..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..908
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 101729 MW; 4A14ED191BCB423E CRC64;
MGDQRALLAA QSGDLATLKR LFEDGVLDRA VTDSLGAGLV HHASRAGQLE CLKFVVERVG
VPGNQRANNG ATPVHDAAAM GNLAELHWLV REGGYRAQEQ DVSGVTPLHL AARFGHPVLL
EWLVQEGCDV SLETLEGALP IHYAAVKGNL TCLKLLVAAD NGCVNRQTQS GASPLYLACQ
EGHLHIVQFL VKDCGVDVHL RAHDGMTVLH AAARSGHYSL VVWLVTFTDI GLMARDDEGA
TVLHFAARGG HAPILDRLLL MGTQIIRDHW GGTPLHDAAE NGHLECCQTL IAHRADPALQ
DGDGYTALDL AVYNGHHECS RYLLEVQKLV RDVLPPPPGF PSPPSVSASW NLVPLKVATI
YNEEKAPEQG KKMEPLNDNK DGLVSFPLEE LNPSDIDALV PTEDENGHSI PEWKRQVMVR
KLQAQLCAPP PPPPPLLSLP RQSSGSDPPD LGDWRYSQIH NAILGPYGEL LTEDDLVYLE
KQIEKLQMRK RCQEYESELG RLAEELQSLL PAPIVNITVN SRFLSPGPDE GGAAADEGQA
LPYWCSHISG LLKSMAGLLK GVNGLARPKE PPAPGASFRV RGGAAGPSGS SAEKEILECG
VSVRSLRDNF EKQADPEPAD GGGGGRGPDE KSPGGPWEAA DAPAAERQAS DDPEEASDSG
ISCEEASSEA GTCPGPAPEA LRKERIVMLF LSHWKKAAYA PALRTAARRT LASREPPLRE
PPLREPPLRE PPLREPAGLG QLLRQRSVIS QLLGNWKDVM GHVPARRPRR PSRPPVTYSP
EMFVPRADGE PVDYHSLSLD LFMLGYFRLL ELELPPDERK MRHLLCFEVF DHLGAHSWET
VRSFHKAVTD EVQAGRRSWR DGFEDIKARF FGGGGGGGGG GPGGGPEPGR RSGLTPVRPP
PGPGARPEPG SFGSPDVCGY IDRSFAFWKE KEAEICNFGD
//
