ID G3VSY7_SARHA Unreviewed; 98 AA.
AC G3VSY7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Gastrin {ECO:0000256|ARBA:ARBA00018558};
GN Name=GAST {ECO:0000313|Ensembl:ENSSHAP00000006292.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006292.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006292.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006292.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC also stimulates smooth muscle contraction and increases blood
CC circulation and water secretion in the stomach and intestine.
CC {ECO:0000256|ARBA:ARBA00003187}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004362}.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000256|ARBA:ARBA00006273, ECO:0000256|RuleBase:RU004362}.
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DR AlphaFoldDB; G3VSY7; -.
DR STRING; 9305.ENSSHAP00000006292; -.
DR Ensembl; ENSSHAT00000006346.2; ENSSHAP00000006292.2; ENSSHAG00000005479.2.
DR eggNOG; ENOG502SA9S; Eukaryota.
DR GeneTree; ENSGT00390000014792; -.
DR HOGENOM; CLU_2249245_0_0_1; -.
DR InParanoid; G3VSY7; -.
DR OrthoDB; 5344034at2759; -.
DR TreeFam; TF336994; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR039236; GAST.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR19309; GASTRIN; 1.
DR PANTHER; PTHR19309:SF0; GASTRIN; 1.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..98
FT /note="Gastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029847632"
FT DOMAIN 83..97
FT /note="Gastrin/cholecystokinin peptide hormone"
FT /evidence="ECO:0000259|Pfam:PF00918"
FT REGION 20..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 10933 MW; 64D83F950320E381 CRC64;
MRQLWGCVLV SALALATFSE ASPKPCQDTP PGPEASRSLG LGLPTPLGSP SHHRRQLRPQ
ELPHLKTDLS KKQGPWLEED EAYGWMDFGR RSAEERDQ
//
