ID G3VTM4_SARHA Unreviewed; 1363 AA.
AC G3VTM4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Kielin cysteine rich BMP regulator {ECO:0000313|Ensembl:ENSSHAP00000006529.2};
GN Name=KCP {ECO:0000313|Ensembl:ENSSHAP00000006529.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006529.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006529.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006529.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSHAT00000006586.2; ENSSHAP00000006529.2; ENSSHAG00000005683.2.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160243; -.
DR HOGENOM; CLU_018024_2_0_1; -.
DR TreeFam; TF351188; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 6.20.200.20; -; 10.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR PANTHER; PTHR46698:SF2; KIELIN_CHORDIN-LIKE PROTEIN; 1.
DR Pfam; PF00093; VWC; 6.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00214; VWC; 14.
DR SMART; SM00215; VWC_out; 7.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57603; FnI-like domain; 15.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS01208; VWFC_1; 9.
DR PROSITE; PS50184; VWFC_2; 13.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 120..175
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 230..289
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 289..348
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 348..406
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 406..465
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 469..527
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 527..584
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 584..643
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 699..762
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 762..820
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 820..888
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 885..948
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 952..1011
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1015..1191
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT COILED 30..57
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1363 AA; 147017 MW; 266200D6BE3050C1 CRC64;
MATLDPGQSA RLDDISHYQQ QAAGHPPTLC ASLEEQLQKV KEQLQELGVL VAELRGQNMD
LQTRVKHLES CECRRPPCTW QGQEWPEGAH WEPDGCTSCV CLQGRAQCSA VRDVTHCLGC
HHGGQAYSSG ETFSLDACTT CHCLDGTVQC LEASCPELHC LESYTPPGQC CPVCRPGDFF
APLPPRGLPV SREGHPYLLR LGSHCPLGNP NVQLLLIVMV MCIPSLCIHA VCVLNGQEFA
EGAHWEPEGQ PCTTCSCLRG VPVCRAVACT PPPCQHPTQS PGTCCPRCES CTYQGHIYAN
GQNFTNPSQP CHTCHCEDGT VLCSPIDCPP TTCIRPQKGP GQCCPRCPDC VLENQVFVDG
ESFSHSRDPC QECQCQGGWV HCQPRACPGP PCAHPLPGSC CKSKCNGCDF GGKEYPNGVD
FPHPTDRCRV CHCINGNVQC LTQRCPPLPC PEPFLSPGEC CPQCPVPPAD CLVPGMPSAH
HQQYFSPPGD PCRRCLCLNG SISCQRLPCP QTFCTHPLQG DCCPSCDGCL YNGKELSNGQ
RFTSQTSPCQ ICLCWEGSVT CEAKSCAPVQ CPFPIQESCC PVCDGCEYLG QRYLSVQEFP
EPENPCNYCT CIGGFVSCDR RPCDQPSCSH PLTLPGHCCP TCEGCFYNGI TTAQGETFPD
PIDSACSYCT CQAGSVQCLK KPCPPALCSH PTPGPCSCPT CQSELSSSGR EYQDGEEFEG
PKGSCEQCYC QAGNVYCKRV LCPSLSCVLQ VTEAGTCCPR CRGCLSPNGE HPEGSSWTPL
DAPCSSCMCH EGVITCARVR CVSSCAHPQQ ESTDCCPLCK DCVYEGQKYE PGESFQPGKD
PCEVCSCELS PGGTPRLRCY RRYCPSLVGC PPNQLLPPGP QNCCPTCTQA LSNCTAGLLG
RELTPPDPCY TCQCQDLTWL CIHRTCPHLS CPPAEQHTVP GTCCPICRAP SPSCSYKGHV
VPSGEHWVVD ECTSCSCVAG TVQCRSQHCS LITCDLEAPV LDPGSCCPRC LPRPASCLAF
GDPHYRTFDG RLFHFQGSCS YVLTKDCHGG DFSIHVTNDD RGRRGVAWTK EVTVLLGDAV
IRLLQDRVVT VDGHTVSLPF LKEPFLYVEL RGGTVFLHAQ LGLQVQWNGQ SQVEVTLPGS
YRGRTCGLCG NYNGFTQDEL QGPSGLLLPS EAAFGNSWQV SEGPGLSQPC SPGREVDPCR
EAGYRARREA NARCAMLKSS AFQRCHQAVP PDPFFAACVY DLCACGTGAS ADACLCDALE
AYAARCRQAG ITPTWRGPTL CVVGCPLDRG FIFDECGPPC PQTCYNRHVP LGELAAHCIR
PCVPGCRCPA GLVEHEAHCI SPESCPPVLL TMEQPITFHT SSN
//
