ID G3VTU1_SARHA Unreviewed; 445 AA.
AC G3VTU1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Nuclear envelope integral membrane protein 1 {ECO:0000313|Ensembl:ENSSHAP00000006596.1};
GN Name=NEMP1 {ECO:0000313|Ensembl:ENSSHAP00000006596.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006596.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006596.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR RefSeq; XP_003772410.2; XM_003772362.2.
DR AlphaFoldDB; G3VTU1; -.
DR STRING; 9305.ENSSHAP00000006596; -.
DR Ensembl; ENSSHAT00000006654.2; ENSSHAP00000006596.1; ENSSHAG00000005742.2.
DR GeneID; 100930639; -.
DR KEGG; shr:100930639; -.
DR CTD; 23306; -.
DR eggNOG; KOG3817; Eukaryota.
DR GeneTree; ENSGT00390000002174; -.
DR HOGENOM; CLU_025225_0_0_1; -.
DR InParanoid; G3VTU1; -.
DR OMA; MAGCMKM; -.
DR OrthoDB; 3091795at2759; -.
DR TreeFam; TF314831; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043131; P:erythrocyte enucleation; IEA:Ensembl.
DR GO; GO:0071763; P:nuclear membrane organization; IEA:Ensembl.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF2; NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 1; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 445 AA; 51389 MW; BB4919007260221D CRC64;
MAGGMKMVPA PPLASRPSSW GPWGGRAAWL RLLLGGCLVC GAAGINIQVV MLQESRFYFG
TNNQQFCYKN TLVPRWHELW TRVTIRVNSS RVVRVTQVEN EEKLKELEQF SLWNLFSSFL
KEKLNDTYVN VDLYSTKVCL KVEVLEKDTK YNISLVRRFD PKLFLVFLLG LLLFFCGDLL
SRSQIFYYST GMSLGILASL LILIFLMSKF MPKKSPVYII LVGGWSFSLY LIQLVFKNLQ
DICRFYWQYL LTYIFIVGIL SFAVCYKYGP LENERSINLL TWTLQLTGLL LMYSGVQIRQ
IAFALIIVAF CTKNLEYPVQ WIYTTYRKVY KAAEKPIPPR LLTEEEYRIQ GEVETRKALE
DLRGYCSSPE CSVWKTISRI QSPKRFADFV EGASHLTPSE VSVHEQEYGL GSNFAEDEIF
EDMSLEDEDE EEFVCPTVLQ NHLMS
//
