ID G3VUM7_SARHA Unreviewed; 2826 AA.
AC G3VUM7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Fibrillin 3 {ECO:0000313|Ensembl:ENSSHAP00000006882.2};
GN Name=FBN3 {ECO:0000313|Ensembl:ENSSHAP00000006882.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006882.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006882.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006882.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9305.ENSSHAP00000006882; -.
DR Ensembl; ENSSHAT00000006941.2; ENSSHAP00000006882.2; ENSSHAG00000005977.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; G3VUM7; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 27.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24040:SF13; FIBROPELLIN-1; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 36.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 2.
DR SMART; SM00181; EGF; 46.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 39.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 39.
DR PROSITE; PS01187; EGF_CA; 18.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2826
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029617321"
FT DOMAIN 113..145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 151..194
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 213..254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 301..354
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 462..501
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 502..543
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 544..584
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 585..625
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 631..683
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 695..736
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 737..778
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 779..818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 823..862
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 882..923
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 928..979
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 999..1040
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1041..1083
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1084..1125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1126..1167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1251..1288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1293..1333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1334..1372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1375..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1417..1453
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1458..1498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1503..1559
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1576..1617
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1618..1655
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1664..1716
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1734..1775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1776..1814
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1860..1895
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1899..1941
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1942..1981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1982..2023
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2028..2081
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2097..2138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2139..2178
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2220..2263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2264..2305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2310..2363
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2375..2412
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2417..2457
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2458..2496
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2497..2539
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2540..2579
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2580..2616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 379..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 117..127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 135..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 466..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 783..793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1864..1874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2544..2554
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2826 AA; 302900 MW; E67AF4FBA447BFD7 CRC64;
MAGSGLTKIL LGWTTLVCMA QAQWEGAIRA DKPGSEEAPA LSRVRRRGFD TLRGPNVCGS
RFHSYCCPGW RTLPGGNQCI VPICRNSCGE GFCSRPNLCA CANGQLSPSC GASGAVCEQS
CQNGGRCIGP NRCACVYGFT GPQCERDYRT GPCFTQVNNQ VCQGQLSGLV CTKTMCCASV
GRAWGHPCEP CPAQPHPCRR GFIPNIRTGA CQDVDECRAI PGLCQGGNCI NTVGSFECRC
PAGHRLGEAS HKCEDVDECS TIPGICEGGE CANTVGSYVC TCPRGFMASA DGSHCLDQRI
GTCFSALLGG RCAGELPGQA SKRQCCCEWG RCWAIGSTPE MCPQRGSDEF RRLCVEGPPV
LPAYPGHFPG LPGFGPNGLG PGLTGPARHG PHGTNGQGSL PSLPGLGPGS SSIGTATLNQ
TIDICKHFTN LCLNGRCLPT SSSYRCECNM GYKQDVRGEC IDVDECSSSP CVHGDCVNTP
GSYHCKCQEG FQSTPTKQSC VDIDECLLNG GMCRHGRCIN TEGSFQCICN AGFEITPDGK
NCVDHDECAT TTMCLNGVCL NEAGSFKCLC KPGFLLAPSG RYCVDIDECE TPGICMNGWC
INTEGSFRCE CVGGLAIGAD GRVCVDTHMR STCYGAIKKG TCARPFPGAV TKSECCCTSP
DHGFGEPCQP CPAKNSDEFQ ALCSSGLGIT ADGRDINECA LNPDICPNGV CENLRGSYRC
ICHLGYEADP PGKECVDVDE CALNRLLCDN GLCRNTPGSY TCTCPTGFTF KTETDSCEDI
DECLSNPCVN GLCRNHAGSF ACECSPGSRL DPAGNVCVDS MKGTCWLQIQ DGRCEANING
ATLRSECCAT LGAAWGSPCQ LCETDPACSR GFARMKGLTC EDVNECEVFP GVCPNGRCLN
TAGSFRCECP EGLTLDSTGR VCVDVRVEQC FLKWDEDECL APLSGKYRMD MCCCSVGAAW
GTGCEACPEP GSPEFALICP RGPGFASRDF LSGRPFYKDV NECKAFPGLC THGSCRNTVG
SFRCVCGNGF ALDAQERNCT DIDECRISPD LCGHGTCVNT LGSFECECFQ GYESGFMMMK
NCMDIDECAR DPLLCRGGTC VNNDGSYQCL CPPGHELSVD GNACEDVNEC SLRDNLCRHG
RCVNVIGTYQ CACDTGFQST PDRQGCIDTD ECSVGNGGCE SQCTNTEGSY QCSCGEGYAL
MPDGRACADI DECEENPDIC DGGQCTNVPG HHRCLCYDGF MATLDMKTCI DVNECDLNPN
ICLHGDCENS KGSFICHCQL GYFVKKGTTG CTDIDECAVG AHNCDARASC VNVPGTFRCM
CQSGWVGDGF KCHDLDECAT EDHGCHINAD CVNSPGSHRC VCREGFSGDG FSCVDRDECA
DNVNLCENGQ CLNAPGGYRC ECEMGFNPTE DSRACQDIDE CTFQNICVFG SCHNLPGMFR
CVCDDGYELD RSGGNCTDIN ECADPVNCIN GLCVNTPGSY LCNCPQDFEL NPSGVGCVDT
RVGNCFLDTQ DRGDGGISCS AEIGVGVTRA SCCCSLGRAW GNPCELCPPG NTTEYKTLCP
GGEGFRPNPI TVILEDIDEC QELPGLCQGG DCVNTFGNFQ CECPLNYYLN EDTRICEDID
ECSTHVGICG PGTCYNTLGN YTCVCPPEYM QVNGGNNCMD VRKSVCYRHH NDTCENELAF
NMTRKMCCCS YNIGKAWNRP CEPCPAPASS EYQILCGNQA PGFIIDIHTG KPIDIDECSE
IPAICTNGVC INQIGSFRCE CPVGFSYNSV LLVCEDMDEC SSGESPCQRH ADCINIPGSY
RCECARGYKL SPSGACVGRN ECQEIANVCS HGDCVDTEGS YACICHQGFK ATVDQTMCMD
IDECDRQPCG NGTCKNTVGS YNCLCFPGFE LTHNSDCMDI DECTSLTGQV CRNGQCINSI
GSFQCLCHEG YERTTDGKNC VDINECVSFP GTCSPGTCQN LDGAFRCICP PGYQVQDDSC
IDINECDEEP NLCLFGTCTN SPGSFQCLCP PGFVLSDNGR RCFDTRQSFC FTRFENGRCS
VPKAFNTTKA RCCCSKMPGE GWGDPCELCP QEGSGAFQEL CPFGHGAVPG PDDSREDVNE
CSENPGICVN GVCINTDGSF RCECPFGYSL DYTGVNCVDM DECSVGNPCG NGVCSNVVGG
FECTCDEGFE PGPMMTCEDI NECSLNPLLC AFRCINTKGS YECTCPSGYM LREDRVMCKD
LDECAEGLHD CPARGMLCKN LIGTFTCICP PGLQLRAHGE GCTDENECRT QPGLCSNGRC
VNTVGSYHCD CNEGFQASPT GTECLDTRQG SCFTEVLQTT CQLSSTNHNP VTKAECCCDG
GRGWGSLCEL CPLPGTAQHR KMCPHGPGYT TDGRDIDECK VLSNLCQNGQ CINTIGSFRC
HCETGYTPDI AGTACVDVDE CEQSPKPCNF LCKNTEGSFK CSCPRGYLLQ GNGKTCKDLD
ECSTKQHNCQ FLCVNTVGSF TCKCPPGFTQ HHHSCLDSDE CMAQPGLCGA QGLCENTPGS
YSCQCQRGFS LDSTGLSCED VDECDGSHHC QHGCRNMVGS YRCGCPNGFT PHSQWDQCVD
DNECSSPTAC GSASCYNTLG SFKCVCPSGY DFDQAFGGCR DVDECSAGGS PCSYGCSNTN
GGYLCGCPGG YFRAGQGHCI SGLGFDKNSY LPTLAEEENE DNLLSPDTCY ECKINGYSQR
SRQRRHTNGT QRHQMSLASV DTEAPLAMAL NLSKLGPREH ILEFLPALEA LENRVLYIIA
HGNEGGFFRM QHKEGLSYLR LGRKKPGPGA YELEVMSVPR PPGDDLGEQA EEGGQALRLK
LQLQLY
//
