ID G3VVW7_SARHA Unreviewed; 1737 AA.
AC G3VVW7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Laminin subunit beta 4 {ECO:0000313|Ensembl:ENSSHAP00000007322.2};
GN Name=LAMB4 {ECO:0000313|Ensembl:ENSSHAP00000007322.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000007322.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000007322.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000007322.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR Ensembl; ENSSHAT00000007384.2; ENSSHAP00000007322.2; ENSSHAG00000006366.2.
DR GeneTree; ENSGT00940000162514; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd22301; cc_LAMB4_C; 1.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR PANTHER; PTHR10574:SF406; LAMININ SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1737
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029846550"
FT DOMAIN 24..264
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 265..331
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 332..394
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 395..454
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 455..505
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 545..801
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 807..854
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 855..900
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 901..948
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1008..1059
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1060..1117
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1118..1165
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1166..1212
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1459..1521
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1586..1613
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1662..1731
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 477..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 489..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 807..819
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 809..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 828..837
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 855..867
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 857..874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 876..885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 920..929
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 932..946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1090..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1118..1130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1120..1137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1139..1148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1166..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1168..1185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1187..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1737 AA; 192884 MW; BF1C51E049D9608E CRC64;
MKFHLTFFMH LVLFRLSKAQ DECISGSCHP IVGDLLLGRS AQLTASSTCG LDGPQKYCII
GYLEGEQKCF ICDSRYPYNP YTQANSHTIE NVITTFESDR KKKWWQSENG LDNVSIRLDL
ETLFQFSHLI MTFKTFRPAA MLVERSVDYG QTWKIFRYFA KDCATSFPNI PSGQAQGVDD
LVCDSKYSDI EPSTEGEVVL KALDPSFEIE NPYSPYIKDL VTLTNLRINF TKLHTLGDTL
LGRRPNDPLD KYYYALYDMV VRGRCFCNGH ANKCGPTQDV RGDVFSPPGM VHGHCICQHN
TDGPNCERCK EFFHDVPWRP AEGLQDNACR SCNCNGHSER CHFDMSLYLS SNSVSGGVCE
DCQHNTMGQH CDQCKPLFYR DPFKEISDPH ACIPCECDPE GSLSGGMCES YPDPVLGIEA
GQCFCKDNVE GPQCDQCKSG YYGLNANDPL GCQSCNCNPL GSVPFSTCDV VTGQCLCQQF
ATGPQCDECL VGYWGLKNNL HSCSPCDCDI GGAYSNLCSP NDGQCECRPH VIGHQCTEPE
PGYFFVPLDF YIYEAEDAMP ISGSAPLILA TALPECEVYF HKQEGSFTID SGNIVLERNK
IQSSREQSEV TSTFDHVVIK DPILGKPVTW TGLGFSQVLS GTNLRFTINN IPYATNYAVA
ISYEPQSSAD WTARMEILPS GPSRSEYCRH KAHLQEPQTL TLPASGRIAL FATPVCLEPG
IQYSIDVHFS QPFIMNSQTH GHILIDSLGL IPQIDSVENF CSKHLDEHQV NNCIEIASKP
HHQILPDWCE RLVVSISARI HNGAVACKCH PQGSIGSSCS KVGGQCQCKP HVTGRCCDRC
STGAYGLGHH GCHPCECHPQ GSKSTICDQI TGQCSCHRDI GGHRCDLCLP GYFGFPNCRP
CPCNGFAELC DPETGSCFNC RGFTAGLHCE RCIDGYYGNP LSGKPCLPCQ CPDVPSSNQY
FAHSCYQNSW NLEVICNCQE GYTGIQCDEC SSGFYGNPKI SGDLCLPCVC NNNIDGADPA
SCSRVTGECL KCLYNTHGPN CQFCKPGYFG SALTQNCRKC TCNPSGVNHT ACAIGDTECL
CDPTTGSCPC LPNVIGLTCD QCAEGYWNLV PRRGCQICEC DPQHSHSTHC DQFTGQCPCK
LGYGGKHCNK CEENYYGDPQ VQCIECKCNK EGTQTAICDQ ETGSCLCRAG VMGHFCDRCA
RGHFQEFPTC LRCPLCFDQW DNEISSLSEA VQGLIRLAAN LEDKRETLPG CNADFKRLED
SMSEAERIWK HPVFSSGEFL NVKDYHDSVR TQVDQISQQV NREYDFQDLN GTLVGIGKEV
DDLLEDLQKK VHLASHVSNS SIRDTSMIEK YYQMSLSAEQ KINDTIFIIK QSENTKNDLL
TMIAGLTSKV NFSREKLKQI QTPDIQKLNE KVCGTPGNLS CILSPCGGAL CKDADEHRIC
GGPNCNGSLS LSRDAAKRAE ETDSMINNLT NQLQLSENQI RNITKLTQLT KTKALQLTEK
LESMKDQIEP EEQRIKALIH KAKDFLLDEN VPPEDIEKVA NHVLDLNLPI TSQNLTKELD
KIDLLMKLCE DDQASGSSLK LKVTETQTLL EKSKDAEETV NTLEEMLKNL KGAESIQRQT
NSVVKQLTDE IQKMEMTILK DFIDLKKQFT ILQNKTNAKG SKKGTLSKVK QLKEEAEKLA
GETEEKMQRI KDLEKKIQVL NQAKQEKVNQ LKQLENHVLA IKNEITTQEN KYSTCHI
//