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Database: UniProt
Entry: G3VWT6_SARHA
LinkDB: G3VWT6_SARHA
Original site: G3VWT6_SARHA 
ID   G3VWT6_SARHA            Unreviewed;      1509 AA.
AC   G3VWT6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-OCT-2019, entry version 57.
DE   SubName: Full=Rho GTPase activating protein 35 {ECO:0000313|Ensembl:ENSSHAP00000007641};
GN   Name=ARHGAP35 {ECO:0000313|Ensembl:ENSSHAP00000007641};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000007641, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000007641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000007641}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AEFK01122837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01122845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000007641; -.
DR   Ensembl; ENSSHAT00000007704; ENSSHAP00000007641; ENSSHAG00000006639.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00950000182819; -.
DR   InParanoid; G3VWT6; -.
DR   OMA; WAPGSDG; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0021955; P:central nervous system neuron axonogenesis; IEA:Ensembl.
DR   GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0043116; P:negative regulation of vascular permeability; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:0008064; P:regulation of actin polymerization or depolymerization; IEA:Ensembl.
DR   GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN      270    327       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      368    422       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      429    483       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      485    550       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      592    767       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      783    948       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1248   1435       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      970    992       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1035   1088       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1125   1147       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1176   1208       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      413    440       {ECO:0000256|SAM:Coils}.
FT   COILED      485    505       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    970    989       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1047   1066       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1181   1195       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1509 AA;  172149 MW;  F180D78E4A81C69D CRC64;
     MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST
     SDFGGRVVNN DHFLYWGEVG RSLEDCVECK IHIVEQTEFI DDQTFQPHRS TALQPYIKRA
     AATKLASAEK LMYFCTDQLG LEQDFEQKQM PEGKLLIDGF LLCIDVSRGM NRNFDDQLKF
     VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF
     STLVQLIDKS RGKMKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKSHNE NWPGVSRKMQ
     SSPEYQDYVY LEGTQKAKKL FLQHTHRLKH EHIERRRKLY LAALPLAFEA LLPNLDEIDH
     LSCIKAEKLL ETKPEFLKWF VVLEETPWDT TSHIDNMENE RIPFDLMETL AAEQLYEAHL
     EKLRNERKRA EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMDIYSKH
     QKQIIDKAKE EFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER
     DALILKHIHF VYHPTKETCP SCPMCVDSKI EHLISSRFIR PSDRNQKNSL SDPNIDRINL
     VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG
     CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL ILVNKRGDTS GETLHSLIQQ
     GQQIASKLQC VFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADI
     DLRIVMCLMC GDPFNTDDIL YPVLQSQTCK PSQGGSNNSV LLELPIIGPH KKRIELSILS
     YHSSFSIRKS RLVHGYIVFY SAKRKASLAM LRAFLCEVQD IIPIQLVALT DCTTDVLDND
     LSREQLTEGE EIAQEIDGRF TNIPCSQPQH KLEIFHPFFK DVVEKKNIIE ATHMYDNVAE
     ACSTTEEVFN SPRASSPLCN SNLPDSEEDI EPSSYSLFRE DTSLPSLSKD HSKLSMELEG
     NDGLPFFSNF ESKLNNKVPP PVKPKPPLHY DKGDLSYLDQ GHKDAQRKSV SSSSWLPADG
     FDPSDYAEPM DAVVKPRNEE ENIYSVPHDS TQGKIITIRN INKAQSNGSA NGSDSEMDTS
     SLERGRKMSM VSKPVLYRTR CTRLGRFASY RTSFSVGSDD ELGPIRKKEE DQASQGYKGD
     NSVIPYETDE DPRRRNILRS LRRNTKKPKP KPRPSITKTT WESNYFGVPL NTVVTPEKPI
     PIFIERCIEY IEATGLSTEG IYRVSGNKSE MESLQRQFDQ DHNLDLAEKD FTVNTVAGAM
     KSFFSELPDP LVPYSMQNDL VEAHKINDRE QKLHALKEVL KKFPKENHEV FKYVISHLNK
     VSHNNKVNLM TSENLSICFW PTLMRPDFSP MDALPATRTY QTIIELFIQQ CPFFFDNRPI
     GEPAGATPSS PASVAPALPF LTSTLWARPW AKPETPESNS FLPFFSLTPC PFPAVRNPPR
     PFPWEVAPR
//
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