GenomeNet

Database: UniProt
Entry: G3VY84_SARHA
LinkDB: G3VY84_SARHA
Original site: G3VY84_SARHA 
ID   G3VY84_SARHA            Unreviewed;       476 AA.
AC   G3VY84;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-OCT-2019, entry version 51.
DE   SubName: Full=ETS proto-oncogene 2, transcription factor {ECO:0000313|Ensembl:ENSSHAP00000008139};
GN   Name=ETS2 {ECO:0000313|Ensembl:ENSSHAP00000008139};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008139, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000008139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000008139}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AEFK01103927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01103928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000008139; -.
DR   Ensembl; ENSSHAT00000008206; ENSSHAP00000008139; ENSSHAG00000007055.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160202; -.
DR   InParanoid; G3VY84; -.
DR   OMA; RSWNSQS; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       88    173       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      368    450       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      273    294       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   476 AA;  54186 MW;  C3FC9195C18980CC CRC64;
     MNDFGIKNMD QVAPVSNYYR GTLKRQPAFD TFECTDSLFE GFFPALNEEQ TLQEVPTGLD
     SVSNESASCE LPLLTPCSKA VMSQALKATF SGFTKEQCRL GIPNNPWLWT EEQVCQWLFW
     ATNEFSLMDV NFQKFIMNGQ VLCNLGKERF LELAPDFVGD ILWEHLEQMI KENQEKTDDL
     YAENSHLTSM PHWINSNSLG GNMDQLSYGM QTQSCTKTTL LDSLCQSSTG PNILSSEQDF
     QLYSKSRLDT INVNYCSVNP DFPGNNLNLL ISNPEGKPGK HDSVENGKDS FESSDSLLQS
     WNSQSSLLDV QRVPSFESFE DDCNQSLCLN KPTMSFKDYI QERSDPVEQG KPVIPAAILA
     GFTGSGPIQL WQFLLELLTD KSCQSFISWT GDGWEFKLAD PDEKKVARRW GRRKNKPKMN
     YEKLSRGLRY YYDKNIIHKT SGKRYVYRFV CDLQNLLGYT AEELHTMLGV QPDTED
//
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