ID G3VZA8_SARHA Unreviewed; 932 AA.
AC G3VZA8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Nuclear factor NF-kappa-B p105 subunit {ECO:0000256|ARBA:ARBA00020838};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000256|ARBA:ARBA00032626};
GN Name=NFKB1 {ECO:0000313|Ensembl:ENSSHAP00000008513.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008513.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000008513.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000008513.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3VZA8; -.
DR Ensembl; ENSSHAT00000008582.2; ENSSHAP00000008513.2; ENSSHAG00000007374.2.
DR GeneTree; ENSGT00940000158625; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08797; Death_NFkB1_p105; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07935; RHD-n_NFkB1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR047096; NF-kB_p105_DD.
DR InterPro; IPR030503; NF-kB_p105_RHD_N.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 44..251
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 604..636
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 638..671
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 672..704
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 384..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 102804 MW; 3DD480C357A7FCB4 CRC64;
MAEEDHYILR MHEQMFQMEP YNIGINAILN SSGLLPADIP LPTADGPYLQ ILEQPKQRGF
RFRYVCEGPS HGGLPGASSE KNKKSYPQVK ICNYVGPAKV IVQLVTNGKH VHLHAHSLVG
KHCEDGICTV TAGPKDMVVG FANLGILHVT KKKVYETLEA RMTDACIRGY NPGLLVHPEL
NYLQPEGGGE RQLTDREKEI IRQAALQQTK EMDLSVVRLM FTAFLPDSTG SFTRRLEPVV
SDAIYDSKAP NASNLKIVRM DRTAGCVTGG EEIYLLCDKV QKDDIQIRFY EEEENGGVWE
GFGDFSPTDV HRQFAIVFKT PKYKDVNITK PASVFVQLRR KSDLETSEPK PFLYYPEIKG
YGFAPYGFSY GGIPFHPGTT KSNAGMKHET LDSSYEQDHE RCDKSDDRDS TEISEKVLQT
TEQEDKSRVT GEDEVSLTCT VGVEEEDCRL QGDLFLEKAM QLAKRHASAL FDYAVTGDVK
MLLAVQCHLT AVQDDNGDNV LHLAIIHLHA ELVRNLLEVI SGLISDDIIN MRNDLYQTPL
HLAVITKQED VVEDLLRAGA DVSLLDRLGN SVLHLAAKEG DDKILSILLK HGKISSLINL
PNGEGLNAIH LAMLINSMPC LRLMIAAGAD VNAQEQTSGR TALHLAVEQE NVSLAGCLLL
EGDAYVDSTT YDGTTPLHIA AGRGSTKLAA LLKAAGADPL LENFEPLFDL DDAWEQDGED
EGVVPGTTPL DMAANSQVYD ILNGKPYQSE STSSDLLVQG DMKQLNEDAK LQLYKLLEMP
DPDKNWSTLA QKLGLGILNN AFRLSPAPSK TLMDNYEVSG GTIRELVDAL REMGYTEAIE
VIQEASNASV NPSEIKEQPV KQIYSLPPSP SSIRQQLGEY KLQDNENVYD SGVETSFHKL
SFTESLTSPG SLITLNKMSR EYGQEASIEG KV
//
