ID G3W0Q4_SARHA Unreviewed; 796 AA.
AC G3W0Q4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009009.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009009.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009009.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3W0Q4; -.
DR STRING; 9305.ENSSHAP00000009009; -.
DR Ensembl; ENSSHAT00000009083.2; ENSSHAP00000009009.2; ENSSHAG00000025529.1.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000161193; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; G3W0Q4; -.
DR OrthoDB; 4637228at2759; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF318; PROTOCADHERIN BETA-8; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..796
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029549354"
FT TRANSMEM 688..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 133..241
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 242..346
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 347..450
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 451..560
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 575..670
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 796 AA; 87863 MW; 00A1E6899DA1DD96 CRC64;
LAGTEGKDRV LQVLFFFVLL CVAGAASELK QFSVVEERER GSFVANVAKA LGLEVGMLSN
RRARVVFKEN KEYLQLNRRT GDLLLREKLD REELCGPADP CVLPFQILLE NPFQIVPAEL
MVEDINDHSP VFLDTETVLK IPESTSPGTV FVLENAQDLD IGSNSLENYT INPNSLFHIQ
IRDSSEGKRY PELVLDKTLD REEKSEVTLT LTAVDGGVPP RSGTAQVRIL VVDINDNAPV
FAQLRYEVQI PENSSIGSKV VTVSATDLDA GNYGEISYTF LHASENIRKT FHLKEELGEL
YLKGKVDFES TQSYTINIQA TDGGGLSAEC TVIVQVMDLN DNPPELTISS LTSPIPENSP
ETVVAVFRVS DLDSGENGKM VCSIQDDLPF TLKPSIENYY TLVTEGALDR EYKDEYNITI
TVIDLGSPRL KSEYNLTVLI SDVNDNSPVF TQRTYKLYLQ ENNGPALHIG SVSASDRDSG
INAKVTYSLL PPESGELPLF SYISINSDNG HLYALRSLDY EAIQTFQFTV RAADGGSPSL
SSQVLVQIVV QDENDNSPFV LYPLQNGTAP CNDLVPRTAE PGYLVTKVVA VDRDWGQNSW
LSYQLLKATD PGLFTLWAHN GEVHTARPIS DKDAIKQRLL VLVKDNGQPP LSTMATINVF
LVDGFSEPYL QLPDGPKEQV QTDSLTTYLI ISLTSVSFLF LASIITFITI HLWKRKRDAA
YGSHFNPNGP FPDHLVNVSG TGTLSQRYQY EVCLTSGSGI SEFKFLKPII PSLSPAEGSG
QNSIENPHLR NSFCFT
//
