ID G3W0Z9_SARHA Unreviewed; 225 AA.
AC G3W0Z9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Ras-related protein Rab {ECO:0000256|RuleBase:RU367128};
GN Name=RAB32 {ECO:0000313|Ensembl:ENSSHAP00000009104.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009104.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009104.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The small GTPases Rab are key regulators in vesicle
CC trafficking. {ECO:0000256|RuleBase:RU367128}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-
CC anchor {ECO:0000256|RuleBase:RU367128}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367128}.
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DR RefSeq; XP_003769574.1; XM_003769526.2.
DR AlphaFoldDB; G3W0Z9; -.
DR STRING; 9305.ENSSHAP00000009104; -.
DR Ensembl; ENSSHAT00000009181.2; ENSSHAP00000009104.1; ENSSHAG00000007886.2.
DR GeneID; 100929670; -.
DR KEGG; shr:100929670; -.
DR CTD; 10981; -.
DR eggNOG; KOG4423; Eukaryota.
DR GeneTree; ENSGT00940000162477; -.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; G3W0Z9; -.
DR OMA; MHYKSTI; -.
DR OrthoDB; 90294at2759; -.
DR TreeFam; TF324491; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0033162; C:melanosome membrane; IEA:Ensembl.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0035650; F:AP-1 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0035651; F:AP-3 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0036461; F:BLOC-2 complex binding; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030742; F:GTP-dependent protein binding; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
DR GO; GO:1903232; P:melanosome assembly; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:0090382; P:phagosome maturation; IEA:Ensembl.
DR GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd04107; Rab32_Rab38; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR030697; Rab29/Rab38/Rab32.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47981; RAB FAMILY; 1.
DR PANTHER; PTHR47981:SF43; RAS-RELATED PROTEIN RAB-32 ISOFORM X1; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU367128};
KW Lipoprotein {ECO:0000256|RuleBase:RU367128};
KW Membrane {ECO:0000256|RuleBase:RU367128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367128};
KW Prenylation {ECO:0000256|RuleBase:RU367128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
SQ SEQUENCE 225 AA; 25114 MW; 5D01A3DB78F07BAE CRC64;
MAGGASGEPG PGAAAGIVVP ETQEHLFKVL VIGELGVGKT SIIKRYVHQL FSQHYRATIG
VDFALKVLNW DSKTLVRLQL WDIAGQERFG NMTRVYYKEA VGAFVVFDIS RESTFEAVLK
WKNDLDSKVQ LANGIPIPTV LLANKCDQNK DNSHSPSQMD QFCKENGFTG WFETSAKDNI
NIDEAVRFLV ENILANYKNF PNEDDVDKIK LDHTTLRAES KSQCC
//
