ID G3W1G5_SARHA Unreviewed; 684 AA.
AC G3W1G5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Premelanosome protein {ECO:0000313|Ensembl:ENSSHAP00000009270.2};
GN Name=PMEL {ECO:0000313|Ensembl:ENSSHAP00000009270.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009270.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009270.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009270.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR AlphaFoldDB; G3W1G5; -.
DR STRING; 9305.ENSSHAP00000009270; -.
DR Ensembl; ENSSHAT00000009350.2; ENSSHAP00000009270.2; ENSSHAG00000008024.2.
DR eggNOG; ENOG502QV5K; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR InParanoid; G3W1G5; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0033106; C:cis-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0033162; C:melanosome membrane; IEA:Ensembl.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:Ensembl.
DR GO; GO:0097487; C:multivesicular body, internal vesicle; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
DR GO; GO:0032438; P:melanosome organization; IEA:Ensembl.
DR GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IEA:Ensembl.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..684
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029697865"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..301
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 312..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 73016 MW; B3F14327848D8743 CRC64;
MAVPLTERMT LRQMIWFYNM AMTCVLLTTI AADGPHEPGW KGARNQPQTN VWDSKLYPEW
TEARIRDLDC WKGGQVTLEV SNDAPTLTGA RVSFSIILHF PASQQVLPNG YIIWTGNGTI
NGSQVWDGQP VYPQDSDAAC VFPDGQPCPS KAGPHRSFIY VWKTWGKYWQ VLGGPVSKLS
IETLGVATGP HTMEVTVYHH RGPRSYVPIA RGLSTFTLTD QVPFSVSVSQ LQALDGGERH
FLRNQPLIFN LQLHDPSSYL SQADLSYTWN FGDGSGTLIS RAPTVTHTYQ ASGPVTAQVV
LEAAIPLTSC RTSPAPGTDL PSTQPLGTTD GKITTSKTPG TTAWEVPTTM ASTPPATEIP
TAVAPGTTTR EAQTIQVPGT TAGEVPTAVF PVTTAEEMPT VAPTANTDEG ISVTDIIRNI
TGTGQTVQSV ETSDMVMVSP GTSPASPEQS TSEVSTTPST TSLRPEATNL PGTTGLSVLP
SAGMAELALV KRQIPLDCIL YRFGSFALTL DIVQGIESAE ILQAVPISEG DAIELTVSCQ
GGLPEEVCTE ISSPGCQLPV QKLCQPVVSS PDCQLVLHQV LEGGAGLYCL NVSLADTNSL
VMASTQLIVP GQETGTQKAP LLVGIMLAMV AIALAFLMYR RVKRGSALPQ SWLPQRTVHW
LRLPSSFYPG PSGESSPLLN GHQV
//
