ID G3W1N9_SARHA Unreviewed; 767 AA.
AC G3W1N9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Transmembrane protein 63C {ECO:0000313|Ensembl:ENSSHAP00000009344.1};
GN Name=TMEM63C {ECO:0000313|Ensembl:ENSSHAP00000009344.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009344.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009344.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR AlphaFoldDB; G3W1N9; -.
DR Ensembl; ENSSHAT00000009425.2; ENSSHAP00000009344.1; ENSSHAG00000008082.2.
DR GeneTree; ENSGT00940000159072; -.
DR HOGENOM; CLU_015647_0_0_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..215
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 231..409
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 421..693
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 767 AA; 89200 MW; 333A0B7F154C6B28 CRC64;
MDPTFPETVS QSTMPLDILN VVERFNNQSL GTCFQTRSVI MRGQSFGGIP TVLILNLCFW
LIAIFVYAFL RKAAWDYGRL SLLTNHESLI SLFFGEQSDK NSPMDPILEV QKRDTGNFSW
LINIIKMTKE ELIKKCGDDA KMYLSFQRHL ILLFLFLCVP SLAVILPLNY SGNLLARNSH
FGRTTIVNVG KNDKILWVHS VFSFLYFCLT FCFMVHHGRD IKPKSEGKAT KTLLVTYLPK
EITDPAIIIK HFHEAYPSCT VTKVHFCYDL RRLVELDNQR HHVMKGRLFY TSYNLANGKT
MIRVHPCSRI CFCQCCKCFK EVDAEQYYSE LEEKLTDEFN AERSLIHQKR LDAAFVTFED
EKMTALILKD FEWIHWGKAP QSSSVTAVVQ SHKWRVFYAP HPKDILWEHL SIRGFHWWAR
FLLINISLFI LIFFLTTPSI VINTMDMFNV TRPIEKLKNP IVTQFVSSLL MWAFAVTLPF
IVYSSSFLEA HWTRSHRNLF TVYKCYFFLV FMVIILPSLG LTSLDLFFRW LLDSTFLDHA
ELKFQCVFLP DNGAFFVNYV ITTSLIGTGS DLLRLESLLF YSIRLLFSKS EGERVNIRQK
QVRTFEYGRE YSWISCVISV VMAYSITCPV IVPFGLLYIC LKHITDKYNL YYSYAPTKLR
EDFHMVGVYQ VILAPILSMF WLLFFSIVRL GSFHPVTVFT LVILFASIVT SFISLCFRKV
WRKRPDTEAE QSDTTSSDFN LRRSISSSLF IQNKKRLESR LQSAVGN
//
