ID G3W3B1_SARHA Unreviewed; 1011 AA.
AC G3W3B1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN Name=EMC1 {ECO:0000313|Ensembl:ENSSHAP00000009916.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009916.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009916.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009916.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
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DR AlphaFoldDB; G3W3B1; -.
DR Ensembl; ENSSHAT00000010003.2; ENSSHAP00000009916.2; ENSSHAG00000008585.2.
DR GeneTree; ENSGT00390000002461; -.
DR HOGENOM; CLU_005034_2_1_1; -.
DR InParanoid; G3W3B1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:Ensembl.
DR GO; GO:0032977; F:membrane insertase activity; IEA:Ensembl.
DR GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; IEA:Ensembl.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..1011
FT /note="ER membrane protein complex subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029910491"
FT DOMAIN 805..1010
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 1011 AA; 113283 MW; A606A9B6A8012DD9 CRC64;
MPGRRRSGPS AGVSIMAAVL AARLWLWAAL LASATAVYED QVGKFDWRQQ YIGKLKFASL
ECAPGSKKMV VATEENVIAA LNSRTGAILW RHVDKGTQEG IIDAMLLHGQ DALTVSNGGR
ILRSWETNIG GLNWEMSLDS GSFQMASLVG LQDVVKYVAV LKKTTLTLHY LSNGHQKWME
QLPKSESVQY QMVYSYGTGV LWVLGVVPNS HVNVVTFHVE DGEMVQQVRV SAPWLKSLSG
VCGVVGKAVL VCPDPGTRSL FTLALETEEE MKRTPLQALE LEFGQGFQPW ILPTQPSPTS
ASRPQFFLQL TPSHFALLQH RPEGLGLLRS FPQTALVNFG TSGEKTVAAV MTCRTETQKG
GSTEEAVTKN ASDKSSTQEA LVCTNQTYTI NLYLAETGRR LLDTSVTFSL EQNGTRPERL
YIQAFLKKDD SVGYRALVQT DDHLLLFLQQ LAGKMLLWSR EESLAEVVSL EMVDLPLTGA
QAELEGEFGK KAAIQDGLLG MFLKRLSSQL ILLQAWTAHL WKMFYDARKP RSQIKNEINI
DNLARDEFNL QKMVVMVTAS GKLFGIESSS GTILWKQYLP NINPDSSFKL MVQRTTAHFP
HPPQCILLVK DKKSGRSSLY VFNPIFGKWS QVAPPVLKRP ILQALLLPIM DQDYAKALLL
IDDEYKVTAF PASRNVLRQL QEMASSIFFY LVDSERGRLS GFRLRKDLTT ELSWELTIPP
EVQKIVMVKG KRATEHVHSQ GRVMGDRSVL YKSLNPNLLA VVTESTDLHH ERTFIGIYLI
DGVTGRIIHS SVQKKAKGPV HLVHSENWVV YQYWNTKARR NEFTVLELYE GTEQYNATAF
SSLDRPQLPQ VLQQSYIFPS SISAMEATIT ERGITSRHLL IGLPSGAILS LPKALLDPRR
PEIPTEQSRE ENLIPYSPDV QIHAERFINY NQTISRMRGI YTAPSGLEST CLVVAYGLDI
YQTRVYPSKQ FDVLKDDYDY VLISSVLFGL VFATMITKRL AQVKLLNRAW R
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