ID G3W3G8_SARHA Unreviewed; 2138 AA.
AC G3W3G8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009973.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009973.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009973.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSHAT00000010060.2; ENSSHAP00000009973.2; ENSSHAG00000008630.2.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001676_0_0_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 1845..2053
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 343..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2138 AA; 241473 MW; E869DEA2A507E770 CRC64;
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES VDLKQFFDQH FSHIYYVFFE
NFVTIEVSLK QKGHKSQREE LDGILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWI FSCLVPGFAS PLSEYGPRTL DNLINPPLNL
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYMVI QVKSLEWKNK ENQEKGFSFL
FSHFKKYYLP YIFPNICKEN TLYHPILDIP QVRPKPHYIM IKKDVESNET IYCTKELFLK
ARVIVIRWLV SFWLEPKPHT GPHIPGIEGE ILPKNIQRAA AGLVSREENK NDSSEKAERT
AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRKV FSSKRSHVNF VTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEEKPLFMK EPEEIEITDI NLPCIESDVE PDVSSEEGKE
KEEEKVTKAS SHVRNSSWTK NGSYQNTLYK GSDMEDADQN IRAGAQLIFQ VFIVNSSNIF
LLEPANEIKS LLDEHTDMCK RILNIYRFMV VQISMDKKTW EQMLLVLLRV TESVLKMPSQ
AFLQYQGRKN MTLAGRLAGP LFQTLIVAWI KANLNVYISR ELWDDLLSVL SSLTYWEELA
TEWSLTMETL TKVLARNLYS LDLNDLPLDK LSEQKQKKHK GKGVGHEFQK TSVDKSFSKG
WSRDQPGQAP MRQRSATTTG SPGTEKARSI VRQKTVAMRS RSIGECALPS VYIRSAKSAP
VLIHTSKPFL PDIVLTPLSD ELSDIDDAQI LPRTTRVRHF SQSEDTGNEV FGTLNEEQPL
PRSSSTSDIL EPFTVERAKA SKEDVSQKLH LLNSDIGSSN ANVPDLMDEF IAERLRSGNT
LNMTRRGSSP GSLEVPKDLP DILEKQNQMR PIDDPGVPSE WTSPASAGSS DLISSDSHSD
SFSAFQYDGR KFDNFSFGVD AATLSSTEID ATLGHQQSTE ELDMASLTTL HIDSETSSLN
QQPFSAEVAT ITGSESVSPI HSALGSRSQT PSPANLNADH IEQKDLQLDE KLQQSVLQTP
DDLETSEFPS ECCSVMAGGT LTGWHADVAT VMWRRMLGIL GDVNTIMDPE IHAQVFDYLC
ELWQNLAKIR DNLGISTDNM TSPSPPVLIP PLRILTPWLF KATMLTDKYK QGKLHAYKLI
CNTMKRRQDV SPNRDFLTHF YNIMHCGLLH VDQDIVNTII KHCSPQFFSL GLPGATMLIM
DFIVAAGRVA SSAFLNAPRV EAQVLLGSLV CFPNLYCVLP ALHPNMPDIA VSQFTDVKEL
IIKTVLSSAR DEPSGPARCV ALCSLGIWIC EELVHESHHP QIKEALNVIC VSLKFPNKTV
AHVACNMLHM LIQYVHRLQI YQPDSPLKII QILIATVTHL LPSTEASSYE IDKRLVVSLL
LCLLDWIMAL PLKTLLQPVH TTGAENDKTE KSVLNCIYKV LHGCVYGAQC FSNPKYFPLS
LSDLASIDYD PFMHLESLKE PEPLHSPDSE RSSKLQPVTE VKTQIQQGLI SVAARTVITH
LVNHLGHYPM NGGPAMLTSQ VCENHDNHYS ESSELSPELF ESPNLQFFVL NNTTLVSCIQ
IKSEESMPGG GLCAGLTSAN SNVRIIVRDL SGKYSWDSAI LYGPPSVKYS SEPVSFMLSL
SHKEKSEDTL ISSECLEDIT VRDGLALQIK KRFRETVPTW DTIRDEEDVL DELLQYLGVT
SPECLQRTGV SLNIPAPQPI CISEKQENDV INAILKQYTE EREFVEKYFN DLNMKAMEQE
EPMPQKPQSA FYYCRLLLNI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS RQCRETHKIA
VFYVAEGQED KHSILTNTGG SQAYEDFVAG LGWEVNLTNH CGFMGGLQKN KSTGLTTPYF
ATSTVEVMFH VSTRMPSDSD DSLTKKLRHL GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI
VIYPMKNHMF SIQIMKKPEV PFFGPLFDGA IVNGKILPIM VRATAINASR ALKSLIPLYQ
NFYEERARYL QSIVQHHLEP TTFEDFAAQV FSPAPYHHST SDTERNAVIV LFLPKPPLES
IGQLKVKAKG SPVLFAGNGV LYQTSMDSHL CLLSAMHF
//
