ID G3W3X2_SARHA Unreviewed; 929 AA.
AC G3W3X2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
GN Name=GPRC6A {ECO:0000313|Ensembl:ENSSHAP00000010127.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010127.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010127.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_003769441.1; XM_003769393.1.
DR AlphaFoldDB; G3W3X2; -.
DR STRING; 9305.ENSSHAP00000010127; -.
DR Ensembl; ENSSHAT00000010216.2; ENSSHAP00000010127.1; ENSSHAG00000008754.2.
DR GeneID; 100932710; -.
DR KEGG; shr:100932710; -.
DR CTD; 222545; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000158416; -.
DR HOGENOM; CLU_005389_1_0_1; -.
DR InParanoid; G3W3X2; -.
DR OMA; ICFICAF; -.
DR OrthoDB; 4224743at2759; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0043200; P:response to amino acid; IEA:Ensembl.
DR CDD; cd06361; PBP1_GPC6A-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..929
FT /note="G-protein coupled receptor family C group 6 member
FT A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003458509"
FT TRANSMEM 589..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 590..852
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 905..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 105401 MW; A1586684F579FAB8 CRC64;
MVLLRILFLC FLTILNFSQP CQIPDDFVAA SSPGHIMIGG LFAVHNKIIH SEKYYRRPEI
QTCEGFEISM FLQTLAMIHS IEMINNSSLL PGVKLGYEIY DTCTEVTVAI AATLRFLSKF
NCSQNIVEFQ CNYSNYTPRV KAVIGASYSE ITMAVSRMLN LQLIPQVSYA STAEILSDKV
RFPSSFRTVP SDFYQTKAMA HLIQKSGWNW IGIITTDDDY GRLALGTFGA QASANNLCIA
FREILPAFLS DSTIEVRINQ TLEKIMEERH VNVIVVFLRQ FHVFNLFNKA IERNINKVWI
ASDTWSAAVK ISTIPNVKRV GKVVGFAFKG GNMSSFHDFI QNLHLMPNEN NKLLSEYIML
LSSCSHVKDN DLNYCIANYS QENWDYRMVE SNFSLRNSFL LHNAEPGHVH SVQLAVSALA
YAIRDQCRDR NCQNPAAFQP WELLEALQNV KFTDGDSEFQ FDSQGDINTG YDVLLWKEIN
GHMTIINMAE YDSEKDVFIF KDSETEKEFS NLKQIQSKCS KECSPGQMKK TTQSQHTCCY
ECVSCPENHY SNQTDMDHCF LCNNKTHWAP VNSTMCFEKQ VEYLSWNDWF AILLLTLSAL
GIVCTFAVGI IFTRNLNTPV VKSSGGLIIC YLILLCHFFS FLSTSFFVGE PQDFKCKARQ
TLFGVSFALC ISCILTKSLK ILLAFSFDPR LQKCLKRLYK PVLIIVICTG VQIIICTMWL
IFAEPFVEEN FSIPQVIILE CDEGSIMAFG TMLGYIAILA FICFISAFKG RKLPANYNEA
KFITFGMLIY FIAWIIFIPI YATTFGKYLP AVEIIVILIS NYGILCCTFF PKCYIILYKQ
ETNTKSAFLK TLYMYSSQSA SSLNVSHISL DSRPSEVPLP NHNFCLKSSV TLEQRKSSQS
QMAGYIQSAR KRTAKNTTGT LPRKRMSSI
//
