ID G3W4P5_SARHA Unreviewed; 306 AA.
AC G3W4P5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Docking protein 5 {ECO:0000313|Ensembl:ENSSHAP00000010400.1};
GN Name=DOK5 {ECO:0000313|Ensembl:ENSSHAP00000010400.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010400.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010400.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010400.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type B subfamily.
CC {ECO:0000256|ARBA:ARBA00006520}.
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DR RefSeq; XP_003757728.1; XM_003757680.1.
DR AlphaFoldDB; G3W4P5; -.
DR STRING; 9305.ENSSHAP00000010400; -.
DR Ensembl; ENSSHAT00000010493.2; ENSSHAP00000010400.1; ENSSHAG00000008979.2.
DR GeneID; 100915815; -.
DR KEGG; shr:100915815; -.
DR CTD; 55816; -.
DR eggNOG; KOG4047; Eukaryota.
DR GeneTree; ENSGT00940000160725; -.
DR HOGENOM; CLU_057256_1_0_1; -.
DR InParanoid; G3W4P5; -.
DR OMA; MECIGTR; -.
DR OrthoDB; 2996885at2759; -.
DR TreeFam; TF324994; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0051386; P:regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
DR CDD; cd14678; PH_DOK4_DOK5_DOK6; 1.
DR CDD; cd13164; PTB_DOK4_DOK5_DOK6; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037816; DOK4/5/6_PH.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF45; DOCKING PROTEIN 5; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 132..237
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
SQ SEQUENCE 306 AA; 35436 MW; 48FB3E49522E1E68 CRC64;
MASNFNDIVK QGYVKIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA AYFRCYHKVT
ELNNVKNVLR LPKSTKKHAI GIYFNDDTSK TFACDSELEA DEWCKVLQME CLGTRINDIS
LGEPDLLATG VEREQNERFN VYLMPSPNLD VHGECTLQIT YEHICLWDIQ NPRVKLISWP
LSALRRYGRD PTWFTFEAGR MCDTGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS
VKNSMLQMKM SERAVSLSTM VPLPRSAYWQ HITRQHSTGQ LYSLQDGSSP LKLHRTETFP
AYRSEH
//
