ID G3W577_SARHA Unreviewed; 724 AA.
AC G3W577;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=GRB2 associated binding protein 1 {ECO:0000313|Ensembl:ENSSHAP00000010582.2};
GN Name=GAB1 {ECO:0000313|Ensembl:ENSSHAP00000010582.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010582.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010582.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010582.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR AlphaFoldDB; G3W577; -.
DR STRING; 9305.ENSSHAP00000010582; -.
DR Ensembl; ENSSHAT00000010675.2; ENSSHAP00000010582.2; ENSSHAG00000009133.2.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000156801; -.
DR HOGENOM; CLU_028652_0_0_1; -.
DR InParanoid; G3W577; -.
DR TreeFam; TF329487; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0090668; P:endothelial cell chemotaxis to vascular endothelial growth factor; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR CDD; cd01266; PH_Gab1_Gab2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF5; GRB2-ASSOCIATED-BINDING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 5..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 194..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 80243 MW; 8FA9C2151E10BAA4 CRC64;
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT
EEDPVKPPGS LQPSADFPLA VSTSPASMPI DLSSSTLPPP YQLINLPPPL EPHPLQDDPQ
DYLLLINCQS KKLEPTRPHA DSAKSTSSET DCNDNVPSHK NSASSQSKHT VNGFFQQQAM
YDPLPSRAVS VSIDSSLYNL PRSYSHDVLP KTASPSSTEA EGELYVFNTP SGTSSLETQM
RHISISYDIP STPGSTYQVP RTFPEGALGQ TSKLETIPDV PPPRPPKPHP AHDRSPVETC
SIARTASDTD SSYSIPTAGV PPSRSNTIST VDLNRMRKDA SSQDSYDIPR TFPSDRSSSL
EGFHAHLKNK SILPMGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIHEA NYVPMTPGTF
DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VTDCEPPPVD RNLKPDRKGQ SPKILRPKPH
GLERTDSQTI GDFATRRKVK PAPLEIKPLP EWEELQAPVR SPITRSFARD YSRFPMSPRP
DSVHSTTSSS DSHDSEENYV PMNPNLSSED PNLFGSNSLD GGSSPMVKPK GDKQVEYLDL
DLDSGKSTPP RKQKSSVSGS NVADERVDYV VVDQQKTLAL KSTREAWTDG RQSTETETPT
KSVK
//
