ID G3W705_SARHA Unreviewed; 976 AA.
AC G3W705;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=MICAL like 2 {ECO:0008006|Google:ProtNLM};
GN Name=MICALL2 {ECO:0000313|Ensembl:ENSSHAP00000011210.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011210.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011210.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011210.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012398273.1; XM_012542819.1.
DR AlphaFoldDB; G3W705; -.
DR Ensembl; ENSSHAT00000011304.2; ENSSHAP00000011210.2; ENSSHAG00000009647.2.
DR GeneTree; ENSGT00940000160222; -.
DR HOGENOM; CLU_015382_0_0_1; -.
DR InParanoid; G3W705; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd21253; CH_MICALL2; 1.
DR CDD; cd09444; LIM_Mical_like_1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR022735; bMERB_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR23167:SF46; ALPHA ACTININ 3; 1.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR Pfam; PF12130; bMERB_dom; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM01203; DUF3585; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51848; BMERB; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 1..107
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 190..252
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 790..941
FT /note="BMERB"
FT /evidence="ECO:0000259|PROSITE:PS51848"
FT REGION 166..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 804..887
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..976
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 106742 MW; D92FB2602E83B69F CRC64;
MAAIKALQQW CRQQCEGYPE VSITNMTTSF RDGLAFCAIL HRHRPDLIDF SKLRKENIYE
NNKLAFQVAE EQLGIPALLD AEDMVALKVP DRLSILTYVS QYYNYFHGRS PIGGMAGVKR
PPTDSIEEPI GKKVISQPVK PASPAPVQPL SPVRTNPIVQ GKSTATEFLP AKPGRVSTPG
SESPRSSRSS VCAICKKHVH LVQRHLVDGK LYHRNCFRCK QCSNTLHSGT YKSTGEPGVF
VCTNHQTKAV TPFSKSPSTD RKQPAAGYPS RTNPVPMDTT SPGVSWRARE PDKPVDAGQK
VSQPVREPVG NSIPKGFVQS FGSPSSVGNS VVNSLSSINP ALHKSTSSTN TPSNSFLNPF
TQNSSAAGGK PSAVTNNSPT GWSSAQRKSD PPTTPSLTKL DYRSTSPQGK SSFSATSQSL
HTSPLSKADS PAGTQSITSQ IKPDFHAASQ IQSNSHTAAS QHKADSSPSS WTSSASKTQQ
ARQKFFQSSE ASAGKAPAPK EYGLTFTSSQ AAGKTPLGVT AAPSQYAKDK ARIFLVKNLM
LGQDSASNGQ EGTTAQGPRR SPTPFRSLTP DPKTEGPRGT PKTKLESASP RPGRVTEFSP
QSKVSAPASP QRTKKSPTFS RPGNELINAR QKPDTSMVNG QGPNSTEEAL DGPAGWRSKL
KPVSVDKVPE LKEKAAPVDI KGPAILKKPL ENSSAGTQSI GSPALKDRSP ASTPTFPKSS
QGPLPGPVAS TALPAGRKKL LIPPNLDVSD SWMKPEQKWE ESIPPEKPSR LNKTEKPCNA
TSFPISVNKE VKSPVKLHPD YMSEEEIQKK IQDIERELDS LELKGVDLER KLREAEGDDS
EDALMVEWFK LIHEKQLLMR QESELMYKAK EQRLEEMQLD IADELRRLME KPEALKTPRE
KKREQELLEQ YVNTVNDRSD IVDCLDEDRI REQEEDQVIQ DMIQKLDLQK DGAEKKKPKR
RLSKIWKPKN KSKTSA
//
