ID G3W7D0_SARHA Unreviewed; 734 AA.
AC G3W7D0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN Name=ELMO2 {ECO:0000313|Ensembl:ENSSHAP00000011335.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011335.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011335.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011335.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR AlphaFoldDB; G3W7D0; -.
DR Ensembl; ENSSHAT00000011430.2; ENSSHAP00000011335.2; ENSSHAG00000009750.2.
DR GeneTree; ENSGT00940000159236; -.
DR InParanoid; G3W7D0; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF8; ENGULFMENT AND CELL MOTILITY PROTEIN 2; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 325..499
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 734 AA; 84240 MW; 6547EDA89CC2B8E5 CRC64;
MKMPPPSDIV KVAIEWPGAN AQLLEIDQKR PLASIIKEVC DGWSLPNPEY YTLRYADGPQ
LYITEQTRSD IKNGTILQLA ISPSRAARQL MERTQSSNME TRLDAMKELA KLSADVTFAT
EFINMEGIVV LTRLVESGTK LLSHYSEMLA FTLTAFLELM DHGIVSWDMV SITFIKQIAG
YVSQPMVDVS ILQRSLAILE SMVLNSQSLY QKIAEEITVG QLISHLQVSN QEIQTYAIAL
INALFLKAPE DKRQDKLLNP LDLPVTDMAN AFAQKHLRNI ILNHVIRGNR PIKTEMAHQL
YVLQVLTFNL LEERMMTKMD PNDQAQRDII FELRRIAFDA ETDPTSVTGS GTEKRKAMYT
KDYKMLGFTN HINPAMDFTQ TPPGMLALDN MLYLAKVHQD TYIRIVLENS SREDKHECPF
GRSAIELTKM LCEILQVGEL PNEGRNDYHP MFFTHDRAFE ELFGICIQLL NKTWKEMRAT
AEDFNKVMQV VREQITRALP SKPNSLDQFK SKLRSLSYSE ILRLRQSERM SQDDFQSPPI
VELREKIQPE ILELIKQQRL NRLCEGSSFR KIGNRRRQER FWYCRLALNH KVLHYGDLDD
NPQGEVTFES LQEKIPVADI KAIVTGKDCP HMKEKSALKQ NKEVLELAFS ILYDPDETLN
FIAPNKYEYC IWIDGLSALL GKDMSSELTK SDLDTLLSME MKLRLLDLEN IQIPEAPPPV
PKEPSSYDFV YHYG
//
