ID G3W7D8_SARHA Unreviewed; 916 AA.
AC G3W7D8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Desmocollin 2 {ECO:0000313|Ensembl:ENSSHAP00000011343.2};
GN Name=DSC2 {ECO:0000313|Ensembl:ENSSHAP00000011343.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011343.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011343.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011343.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_012396815.1; XM_012541361.1.
DR AlphaFoldDB; G3W7D8; -.
DR STRING; 9305.ENSSHAP00000011343; -.
DR Ensembl; ENSSHAT00000011439.2; ENSSHAP00000011343.2; ENSSHAG00000009756.2.
DR GeneID; 100923222; -.
DR KEGG; shr:100923222; -.
DR CTD; 1824; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT01030000234624; -.
DR HOGENOM; CLU_005284_2_0_1; -.
DR InParanoid; G3W7D8; -.
DR TreeFam; TF316817; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0086073; P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025:SF0; DESMOCOLLIN-2; 1.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..916
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029515232"
FT TRANSMEM 697..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 136..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 244..355
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 356..476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 473..578
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 916 AA; 101361 MW; 7370EBD944460FFB CRC64;
MAAEGPGQSR FIAGCGLLLL TLQVLSFSCE ACKRVILTVP SKLEAETFVG RVNLDECLPS
ANIIHSNDPH FKIFKDGSVY TTNTIVLSPE KRNFTIQLSN TQKRELKNIV VLLEYQKKVL
KKRHLKETVL KRAKRRWAPI PCSLPENSLG PFPMYLQQVQ SDSAQNYTVY YSIRGPGVDQ
EPLNLFYIER DSGKLFVTRP VDREKCSSYG LIAYASTPDG YSVDMPLPLE IRVEDENDNY
PIFTENPYQF EVLENSGAGT TVGQVCATDA DEPDTMHTRL KYTIIEQQPP SPTLFSIHPV
TGVITTTSSR CDREVVDKYK LTLKVQDMDG QYFGKFTKST CIISVGDVND NLPIFTRTSY
VTEVEENKSN VEILRLAVED KDLINTPNWS ANYTILRGNE NGNFHIVTDP KTNEGILCVV
KGLNYEETRQ VVLQIGVTNQ AAFFGSGGSK TTGMSTTTVT VNVKDQDEGP ECTPQMQTVH
VKENAVLGTQ FNGYKAYDPE TRSNSGIRYQ TLNDAKGLFT IDETSGSIKV LRSLDRESNT
FRHGSYNITV RAADRDGRTC TGILRIIVDD VNDNGPVISQ KSVIICKTQM GSAEIVAVDP
DEPINGPPFE FTLPSSSSRV NDGMWRLSKI NDTATRITFR NDPGFGVYDI PIEVRDRFGL
SKTNVLSVNL CDCVVPSECT TRAVLMQGAN DVRLGKWAIL AMILGAALLS CILFTLVCGA
AGSSPAKKPF PDDLAQQNLI VSNTEAPGDD RVYCTNGLTT QNVNTGCTLV SGVKNGQESF
EMMKGGHQTL ESCQGGGHHT LDSCRGGHHT LDSCRGGHHT LDSCRGGQVE MDNCRYTYSE
WQNFTQPRLG EKVQMCNQNE DQTHAQDYVL TYNYEGRGSA AGSVGCCSER HEEEGLEFLD
HLEPKFRTLA EACMKR
//
