ID G3W8P7_SARHA Unreviewed; 634 AA.
AC G3W8P7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Kelch like family member 14 {ECO:0000313|Ensembl:ENSSHAP00000011802.2};
GN Name=KLHL14 {ECO:0000313|Ensembl:ENSSHAP00000011802.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011802.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011802.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011802.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3W8P7; -.
DR STRING; 9305.ENSSHAP00000011802; -.
DR Ensembl; ENSSHAT00000011899.2; ENSSHAP00000011802.2; ENSSHAG00000010132.2.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159556; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; G3W8P7; -.
DR TreeFam; TF328485; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR CDD; cd18453; BACK_KLHL14; 1.
DR CDD; cd18243; BTB_POZ_KLHL14_printor; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR047027; KLHL14_BACK.
DR InterPro; IPR030584; KLHL14_BTB_POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF6; KELCH-LIKE PROTEIN 14; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 2.
DR Pfam; PF01344; Kelch_1; 5.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 2.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..157
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 68..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 71605 MW; FC2D6459666DB188 CRC64;
MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS
LFSSHPPLGG GVGGQDGLGA PKDPQQQQQQ QQQQQQQQQQ QQQQQQQEEP GTPSSSPDDK
LLASPRAINN LVLQGCSSIG LRLVLEYLYT ANVTLSLDTV EEVLSVSKIL HIPQVTKLCV
QFLNDQISVQ NYKQVCKIAA LHGLEETKKL ANKYLVEDVL LLNFEEMRAL LDSLPPPVES
ELALFQMSVL WLEHDRETRM QYAPDLMKRL RFALIPAPEL VERVQSVDFM RTDPVCQKLL
LDAMNYHLMP FRQHCRQSLA SRIRSNKKML LLVGGLPPGP DRLPSNLVQY YDDEKKTWKI
LTIMPYNSAH HCVVEVENFL FVLGGEDQWN PNGKHSTNFV SRYDPRFNSW IQLPPMQERR
ASFYACRLDK HLYVIGGRNE TGYLSSVECY NLETNEWRYV SSLPQPLAAH AGAVHNGKIY
ISGGVHNGEY VPWLYCYDPV MDVWARKQDM NTKRAIHTLA VMNDRLYAIG GNHLKGFSHL
DVMLVECYDP KGDQWNILQT PILEGRSGPG CAVLDDSIYL VGGYSWSMGA YKSSTICYCP
EKGTWTELEG DVAEPLAGPA CATVILPACV PYNK
//
