ID G3WAW1_SARHA Unreviewed; 1697 AA.
AC G3WAW1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Protein unc-13 homolog A {ECO:0008006|Google:ProtNLM};
GN Name=UNC13A {ECO:0000313|Ensembl:ENSSHAP00000012566.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012566.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012566.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012566.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9305.ENSSHAP00000012566; -.
DR Ensembl; ENSSHAT00000012670.2; ENSSHAP00000012566.2; ENSSHAG00000010759.2.
DR eggNOG; KOG1011; Eukaryota.
DR GeneTree; ENSGT00940000154929; -.
DR HOGENOM; CLU_001304_3_0_1; -.
DR TreeFam; TF312844; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF1; PROTEIN UNC-13 HOMOLOG A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 545..595
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 651..775
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1085..1228
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1337..1479
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1512..1639
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 181..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..360
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1697 AA; 192567 MW; 824B059FF553F15D CRC64;
MSLLCVGVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG NLPCWEQDFM FEINRLDLGL
TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQVIMTDNEI CGTKDPTFHR
ILLDTRFELP LDIPEEEARY WAKKLEQLNA MRDQDDYSFQ EEQDKPLPVP SSQCCNWSYF
GWGEQQNEDP DSAVDDRDSD YRSETSNSIP PPYYTTSQPN ASVHQYSVRP PPLGSRDSRD
SYSDSMRSYE DYSEAPPVSP TGSSRYASSG ELSQGSSQLS EDFDPDDQSL QGSEIEEERD
RDSYHSCHSS VSYHKDSPHW DQNEEEEEED LEEEEEEDLE EEDLEDLEDL EDEELRQEGY
SENEEEYSKE ESYPPTAPTT SEREEKPSPV STEVPEVAKM PPEPAGAEEV PGAERAPEPE
PPKLEERARE DEEGQDSMSR AKANWLRVFN KVRMQLQEAR GEGDMSNSLW FKGGPGGGLI
IIDSMPDIRK RKPIPLVSDL SLVQSRKAGI TSALASSTLN NEELKNHVYK KTLQALIYPI
SCTTPHNFEV WTATTPTYCY ECEGLLWGIA RQGMRCTECG VKCHEKCQDL LNADCLQRAA
EKSSKHGAED RTQNIIMVLK DRMKIRERNK PEIFELIQEI FAVSKTTHTQ QMKAVKQSVL
DGTSKWSAKI SITVVCAQGL QAKDKTGSSD PYVTVQVGKT KKRTKTIYGN LNPVWEENFH
FECHNSSDRI KVRVWDEDDD IKSRVKQRFK RESDDFLGQT IIEVRTLSGE MDVWYNLDKR
TDKSAVSGAI RLHISVEIKG EEKVAPYHVQ YTCLHENLFH FVTDVQNSGA VRIPDAKGDD
AWKVYYDETA QEIVDEFAMR YGVESIYQAM THFACLSSKY MCPGVPAVMS TLLANINAYY
AHTTASTNVS ASDRFAASNF GKERFVKLLD QLHNSLRIDL SMYRNNFPAS SPERLQDLKS
TVDLLTSITF FRMKVQELQS PPRASQVVKD CVKACLNSTY EYIFNNCHEL YSREYQTDPA
KKGEVPPEEQ GPSIKNLDFW SKLITLIVSI IEEDKNSYTP CLNQFPQELN VGKISAEVMW
NLFAQDMKYA MEEHDKHRLC KSADYMNLHF KVKWLYNEYV TELPSFKDRV PEYPAWFEPF
VIQWLDENEE VSRDFLHGAL ERDKKDGFQQ TSEHALFSCS VVDVFSQLNQ SFEIIKKLEC
PDPQIVGHYM RRFAKTISNV LLQYAEIISK DFTTYCSKEK EKVPCILMNN TQQLRVQLEK
MFEAMGGKEL DAEASDILKE LQVKLNNVLD ELSRLFATSF QPHIEECVKQ MGDILSQVKG
TGNVPASACS SVAQDADNVL QPIMDLLDSN LTLFAKICEK TVLKRVLKEL WKLVMNTMEK
TIVLPPLTDQ TGTQMIFNAA KELGQLSKLK DHMVREEAKS LTPKQCAVVE LALDTIKQYF
HAGGVGLKKT FLEKSPDLQS LRYALSLYTQ ATDLLIKTFV QTQSAQVHGG KGIRFTLSEE
IYPEKGSGVD DPVGEVSVHV ELFTHPGTGE HKVTVKVVAA NDLKWQTSGI FRPFIEVNII
GPQLSDKKRK FATKSKNNSW APKYNETFQF TLSADAGPEC YELQVCVKDY CFAREDRTVG
LAVLQLKELL QRGSCACWLP LGRRIHMDDT GLTVLRILSQ RSNDEVAKEF VKLKSDTRSA
EEGGAGPGPG SGQGPGP
//
